We've been collaborating with Satish Nair's lab (Illinois) on the structure of the lasso peptide isopeptidase, an enzyme that specifically cuts open lasso peptides. Read all about in JACS.
The Link Lab is now on Twitter. Follow us: @ajlinklab
A couple of new exciting papers have come out. Wai Ling's photocrosslinking work on the lariatin system was published at ACS Central Science a few weeks ago and Caitlin's lasso peptide catenane paper was accepted at JACS this week. Check them out: lariatin and catenane.
Our collaborative paper with Andy Ferguson on lasso peptide unthreading was published today at ACS Chemical Biology. Check it out here if you want to see how slipknots unthread at the nanometer scale. The work in our lab started out as Maria Chen '14's thesis, continued as Nini Le '15's thesis, and finished by Caitlin Allen. Alex Trick worked on the computational aspect in Andy's lab at Illinois for his undergraduate research.
A new semester means new senior thesis students. Welcome to Aded, Garrett and Shubham from CBE who are joining Aastha from MOL for their senior thesis in the Link Lab.
Caitlin successfully defended her thesis today. Congrats Caitlin!
Congratulations to the newest Link Lab alumni who graduated today: Kenny, Caroline, Jason, Chad, and Lawrence! Stay in touch, and you're always welcome in Hoyt Lab!
Our paper on lasso peptide isopeptidase substrate specificity has been accepted at JBC. Congrats to Mikhail, Joe, Bozhena, and Chuhan! Read the paper here.
Chuhan and Mikhail's paper on lasso peptide fusion proteins has been accepted at ACS Chemical Biology. Check it out here.
We have 5 members of the class of 2016 doing their senior thesis research in the lab: Caroline, Chad, Jason, Kenny, and Lawrence. Read all about them on the people page!
Undergrads Caroline Kim (Class of 2016, mol bio) and Cat Nguyen (Class of 2017, CBE) have joined the lab for summer research experience. Welcome!
Alan's paper on the ERK/Capicua interaction has been accepted at PNAS! Congrats, Alan. Read the paper here.
Congrats to Nini Le, Ariel Kunkel, and Caitlin Wood, who graduated today! Please stay in touch as you move on to bigger and better things!
Welcome to Chad Wangsanuwat '16 and Steven Tsai '17 who are carrying out independent work in the lab this spring.
Some personnel changes in the group: Mikhail has successfully defended his thesis! Congratulations Dr. Maksimov! Mikhail has been working at Illumina since November 2014. Also, first-year grad student Wai Ling Cheung has joined the group. Welcome Wai Ling!
Our paper with the Liu lab at Texas A&M has been accepted at ChemComm. This paper merges two long-standing interests in the lab: lasso peptides and noncanonical amino acids. Read it here.
Diya, Frank, and Siyan's paper on protein stapling has been accepted at ChemComm! Read all about it here.
Our group welcomes two high school students for the summer: Akhil Dondapati and Karen Zhang. Akhil is a rising senior at West Windsor-Plainsboro High School South and Karen is a rising senior at the Lawrenceville School.
A bunch of Link lab senior thesis students graduated. Cathy Chen is headed to medical school at the University of Mississippi, Maria Chen is pursuing an MD/PhD at Baylor, Bozhena Lisko is working at Goldman-Sachs, Allyse Terrell is working at Capital One, and Michelle Wu will be joining Stanford for a PhD. Yan Wu, who spent time in the lab from the summer before his senior year in high school through his junior year at Princeton, also graduated and will be headed to UCSD for a PhD.
Our latest paper on enzymes that can "untie" lasso peptides has been accepted at JACS. Check it out here.
After completing his third rotation in the Link Lab, molecular biology grad student Joseph Koos has joined the group. Welcome Joe!
Edwin, Eugenia, Hannah, Jen, and Santiago graduated and are off to bigger and better things. Congrats to all!
Mikhail has been awarded a Dodds Fellowship, one of Princeton's honorific fellowships. Congrats Mikhail!
Jamie has been promoted to Associate Professor effective July 1.
Jamie is named a 2013 Sloan Research Fellow in Chemistry!
New grad students Jack Lu and Frank Piscotta from Chemical and Biological Engineering and Chuhan Zong from Chemistry have joined the Link Lab. Welcome!
Our paper on lasso peptide discovery has been accepted at PNAS! Congrats to Mikhail, and click below to read the paper.
Students from last year's Project SEED cohort are featured in a video on the ACS website. Much of this video was shot in the Link Lab! Check out the video at the link below and click on the outreach tab to learn more about Project SEED at Princeton.
Our review article on lasso peptides has been accepted at Natural Product Reports. Click below to read the paper.
Today's graduation ceremony had six Link Lab members getting their degrees. Diya, Jessica, and Siyan received their PhDs while John, Mehek, and Michelle received their BSEs.
Diya and Jessica both defended their PhD theses this week. Congratulations, Dr. Abdeljabbar and Dr. Pan!
Siyan successfully defended her thesis. Congratulations, Dr. Zhang! Siyan will be joining Merck and Co. in August.
Our paper on lasso peptide leader peptides is accepted at ChemComm. Congrats to Jakub, Jessica, and Mikhail!
Jessica, Jakub, and Wai Ling's paper is accepted at ChemBioChem.
Siyan and Angel's paper on BH3 peptide affinity maturation was accepted at ACS Synthetic Biology. Congrats!
Diya's paper on fungal cellulase expression in E. coli was accepted at Biotechnology Letters.
Jamie is named a DuPont Young Professor. We are grateful to DuPont for their support of our research.
Siyan's paper on Bcl-2 family interactions was accepted at Integrative Biology!
Seniors Angel Long and Jakub Rajniak graduated. Angel will be heading to med school at Duke in the fall while Jakub will be purusing a PhD in Chemical Engineering at Stanford. Jakub was recognized at Class Day with the Hayes-Palmer Prize for overall academic excellence. You will both be missed, so please stay in touch!
Our paper on azidonorleucine was accepted at ChemBioChem. Congrats, Diya and TJ!
Siyan's paper on PCR nanobeads is accepted at Nano Letters! Congratulations, Siyan!
Jessica's paper on microcin J25 engineering is accepted at JACS! Here is a link to the paper.
Mikhail passed his first proposition exam. Congrats, Mikhail!
First year grad student Alan Futran joins the group. Alan will be co-advised by Prof. Shvartsman. Welcome, Alan!.
Siyan's paper on nanoparticles was accepted at Polymer Chemistry.
Our collaborative paper with Profs. Panagiotopoulos and Debenedetti was accepted at Biophysical Journal. Congrats to Andy, Siyan, and Igor!
Jayne, Wai Ling, and Molly graduated. Congrats and please stay in touch in the future!
Wai Ling receives two awards for her senior thesis work on lasso peptides: the departmental Merck & Co. award and the SEAS-wide MacCracken Prize. Congrats, Wai Ling!
Current Link lab members and alumni gathered during reunions for the first annual Link Lab barbeque. It was a lot of fun to see everyone again!
Jamie receives the E. Lawrence Keyes, Jr/Emerson Electric Co. Faculty Advancement Award in Engineering
Prof. Link is awarded an NSF CAREER grant.
Wai Ling and Jessica have their work on the microcin J25 leader peptide published in JACS.
Mikhail Maksimov joins the Link Lab. Welcome, Mikhail!
Jessica and Wai Ling’s paper on engineering the production of microcin J25 is accepted at Protein Expression and Purification.
Diya, TJ, and Siyan’s paper on the incorporation of azidonorleucine into proteins in E. coli strains carrying a single genomic copy of an engineered MetRS is published at JACS. Congrats!