What are the functional consequences of immunological complexity – for example, feedback loops within the cytokine network?
Cytokines form an intricate signalling network, with positive and negative feedback loops (e.g., between pro- and anti-inflammatory cytokines) that ultimately determine how well the host fights infection. Our multiplex data – on responses to malaria in the presence and absence of helminth co-infection – allow us to test whether cytokines are additive or multiplicative in their effects upon parasite replication. Using molecular interventions, we are also assessing the robustness of the signalling network to perturbation.
< Back to research questions