501 Introduction to Quantum Chemistry
Basic development of quantum theory and the Schroedinger equation. Single-particle potential problems, an introduction to angular momentum theory, and operator concepts and electron structure.

502 Advanced Quantum Chemistry
Typical topics covered include advanced aspects of angular momentum theory, scattering, time dependent processes, and interaction of radiation with matter. Specialized topics are included at the discretion of the instructor.

503/APC 512 Introduction to Statistical Mechanics
Understanding equilibrium and nonequilibrium properties of matter in terms of the microscopic details of molecular interactions and structure. Topics include Gibbs ensembles, microscopic basis of the laws of classical thermodynamics, noninteracting systems, virial expansion, distribution function theory, Monte Carlo and molecular dynamics simulation techniques, critical phenomena, percolation theory, renormalization group methods, and Boltzmann equation and applications.

504 Molecular Spectroscopy
A survey of atomic and molecular energy levels and the Hamiltonians that describe them. The interaction of radiation with matter, including multiphoton effects. Examples include electronic and nuclear spectroscopy of molecules and crystals, electron spin resonance, microwave spectroscopy, and the uses of lasers in modern spectroscopic research.

505 Group Theory in Chemistry
An introductory survey course in chemical applications of group theory, including symmetry and permutation groups of rigid molecules, space groups, representations, and character tables and selected topics in spectroscopy and chemical reactions. Selection of applications is based on student interest.

506 Chemical Bonding
Theories of the chemical bond and intermolecular interactions and quantum mechanical methods and their use in predicting and interpreting chemical phenomena are studied. Illustrative examples are drawn from organic, inorganic, physical, and biological chemistry.

507 Solid State Chemistry
Crystal types and binding energies; crystal structure and symmetry; reciprocal lattice, Brillouin zones, energy bands, and Fermi surfaces; impurity states; energy transport in ionic, molecular, and semiconducting crystals; magnetism and spin waves; and chemistry and photochemistry in the solid state.

509, 510 Topics in Physical Chemistry
Topics covered vary from year to year and are selected from the following: state-selected chemical processes; high-resolution spectroscopy; energy transfer and redistribution; laser-induced chemistry; surface chemistry; electronic properties of conjugated polymers; nonlinear optical materials; physical electrochemistry; heterogeneous reaction dynamics; spectroscopy and dynamics of clusters; and chaotic systems.

511/MSE 513 The Chemistry and Physics of Nanomaterials
The first part of the course contains fundamental chemical concepts and basic ideas needed to calculate the difference between the bulk properties of matter and the properties of aggregates. The second part describes the tools needed to probe matter at the nanoscale level. The third part discusses examples of nanoscale materials (clusters, monolayers, fullerenes, biomolecules) and their applications.

512 Chemical Kinetics
Discussion of reaction rate theory, molecular dynamics and experimental techniques.

515, 516 Physical Biochemistry
Comprehensive introduction to major contemporary techniques used to study the structures, functions, and interactions of biological macromolecules, with an emphasis on applications rather than theory. Particular stress is laid on the strengths and limitations of individual methods and the complementarities among them. Methods covered include spectroscopies (UV, florescense, CD, and NMR), X-ray diffraction, hydrodynamic and transport methods (sedimentation and diffusion), and miscellaneous methods.

521 Organometallic Chemistry
Familiarizes the student with basic principles of structural reactivity of transition metal organometallic chemistry.

522 Advanced Inorganic Chemistry
Advanced topics in inorganic chemistry, including solid-state and bioinorganic chemistry, band theory, and reaction mechanisms.

523 Coordination Chemistry
Chemistry of transition metal complexes and ligand field and molecular orbital theory.

524 Topics in Inorganic Chemistry
Topics covered vary from year to year and are selected from the following: inorganic spectroscopy and applications to chemical bonding in transition metal complexes; homogeneous catalysis based on transition metal systems; noninnocent ligand and fluxional processes; organic synthesis via organometallic reagents and the mechanisms of these reactions; metal clusters; stereochemistry of inorganic reactions; and bioinorganic chemistry.

526 Organometallic Chemistry II
Structure-reactivity correlations for inorganic complexes; and ligand substitution and electron transfer processes in the context of a variety of inorganic processes, including external reagent attack on a metal complex at the metal center or at a coordinated ligand, carbon-carbon bond formation, and oxidation processes are studied.

GEO 501/527 Physics and Chemistry of Minerals and Materials
Concepts of solid-state physics and inorganic chemistry relevant to the study of minerals and materials. The emphasis is on applications to the study of planetary interiors. Topics include crystal chemistry; crystal structure and phase transitions; equations of state, dynamic, and static compression; elasticity; transport properties; lattice dynamics; lattice defects; and solid-state diffusion and creep.

530 Synthetic Organic Chemistry
Methods for introduction and modification of functional groups, formation and cleavage of bonds; selection and employment of protecting groups; control of stereochemistry; manipulation of polyfunctional molecules; design and use of selective reagents; and multistage syntheses are studied. These areas of study are illustrated with examples of outstanding achievements in the total synthesis of complex molecules.

531 Advanced Organic Chemistry
Geared toward graduate students interested in synthetic organic chemistry, the course covers general strategies for the stereocontrolled formation of carbon-carbon bonds as well as basic concepts in physical organic chemistry that shed light on regio- and stereo-control in organic reactions.

532 Mechanistic and Physical Organic Chemistry
The ways in which molecules are changed into other molecules are studied. Some topics include mechanisms of acid and base catalyzed reactions, nucleophilic and electrophilic displacements and substitutions, addition and elimination reactions, condensations, inter- and intramolecular rearrangements, electrocyclic ring openings and closings, and sigmatropic shifts.

533 Heterocyclic Chemistry
The properties and synthesis of heterocyclic compounds containing nitrogen, oxygen, and sulfur relationships between structure and chemical and physical properties and the general principles of reactivity and synthesis are studied. Topics include electrophilic, nucleophilic, and homolytic substitution reactions; the chemistry of N-oxides and N-ylides; photochemistry; molecular rearrangements and ring transformations; and modern synthetic methodology and design.

535 Topics in Stereochemistry
The fundamentals of the subject are explored. Selected topics, with an emphasis on the relation of symmetry to molecular structure and the physical properties of organic compounds are studied.

536 Topics in Organic Chemistry
The course will focus on using multipulse and multidimensional NMR spectroscopy techniques for structure elucidation and characterization of complex organic molecules. Prior fundamental knowledge of NMR is assumed. Technology and application of selective irradiation 1D and a variety of nD methods, including optimal parametrization, data processing and data analysis will be discussed in detail; design and applications of multidimensional homo- and heteronuclear correlation spectroscopy, gradient-based and diffusion-based methods; rational strategies for structure determination and verification will be demonstrated using real life examples.

537 Organometallic Reagents in Organic Synthesis
An advanced course dealing with the applications of organo-transition metal reagents in organic synthesis. Emphasis is placed on systems already in use. Discussion of the scope and limitations of the methods in terms of mechanism is held. A prior course in organometallic chemistry (Chemistry 521) is recommended.

538 Topics in Biological Chemistry
The chemical mechanisms of enzyme-catalyzed reactions are studied. The nature and sequence of events at enzyme active sites, emphasizing the participation of prosthetic groups and amino acid side chains in catalysis are also studied. Topics discussed include the use of kinetic, spectroscopic, and structural data as well as substrate analog and isotopic substitution studies for analysis of enzyme mechanisms.

539 Introduction to Chemical Instrumentation
The operation and application of instrumentation used in modern chemical research is covered. Emphasis is on proton and carbon NMR. Pulsed-Fourier transform and 2D-NMR techniques are described. The course also has a laboratory section in which the students get hands-on exposure to FT-NMR and other spectrometers.

542 Principles of Macromolecular Structure
Structures and properties of biological macromolecules. The forces and interactions that direct biological polymers to adapt particular 3-dimensional structures are discussed from both a structural and a thermodynamic perspective. Special emphasis is placed on recent experimental work probing the folding and stability of proteins as well as on the design of novel proteins.

543 Advanced Topics in Structural Biology
Structural biology of human diseases. A critical discussion of protein structures of medical interest such as antibodies, histocompatibility complexes, growth factors, receptors, T-cell activation, G-coupled receptors, viruses, and bacterial toxins. The structural basis of signal transduction is treated in terms of high-resolution crystal structures of kinases and phosphatases. Special emphasis is placed on methods used to obtain and interpret results by X-ray crystallography.

544 Inorganic Chemistry of Life
A course in inorganic physiology and biochemistry, presenting the chemical principles adopted by nature to perform biological functions. Topics include metal ion function in protein and nucleic acid structure, metalloenzyme mechanisms, metal regulation of gene expression, biological energy conversion via ion pumping, storage and mobilization of the elements, and biomineralization.

558/MOL 558Chemistry, Structure, and Structure-Function Relations of Nucleic Acids
The chemistry and structure of mononucleotides, oligonucleotides, and polynucleotides and their helical complexes as a basis for understanding and predicting the structures and structure-function relations of naturally occurring DNAs and RNAs.


Pertinent Courses in Allied Departments
Chemical Engineering

541 Chemistry of Polymer Materials
542 Polymeric Liquids and Networks
543 Solution Properties of Polymers
553 Topics in Interfacial Chemistry

Geosciences
512 Thermochemistry in Geological and Materials Science
522 Hydrothermal Geochemistry

Molecular Biology
505 Molecular Biology of Prokaryotes
506 Molecular Biology of Eukaryotes
523 Molecular Basis of Cancer
547, 548 Special Topics in Molecular Biology

Physics
507, 508 Quantum Mechanics II