TISSUE MORPHODYNAMICS LABORATORY
 
Publications
Please note: Reprints are provided for personal use only.
  86. Piotrowski A.S., Simi A.K., Pang M.F., Tien J. & Nelson C.M. (2014) A three-dimensional culture model to study how fluid pressure and flow affect the behavior of aggregates of epithelial cells. In Mammary Gland Development (Methods in Molecular Biology series) (eds. Martin F. & Stein T.), in press.
  85. Simi A.K., Piotrowski A.S., & Nelson C.M. (2014) Mechanotransduction, metastasis, and genomic instability. In Genomic instability and DNA repair in cancer progression and metastasis (eds. Maxwell C. & Roskelley C.), in press.
  84. Varner V.D. & Nelson C.M. (2014) Cellular and physical mechanisms of branching morphogenesis. Development, 141: 2750-2759. [pdf]
  83. Schawrz U., Nelson C.M., & Silberzan P. (2014) Proteins, cells, and tissues in patterned environments. Soft Matter, 10: 2337-2340. [pdf]
  82. Jakus Z., Gleghorn J.P., Enis D., Sen A., Chia S., Liu X., Rawnsley D., Yang Y., Hess P., Zou Z., Yang J., Guttentag S., Nelson C.M., & Kahn M.L. (2014) Lymphatic vascular function is required perinatally for lung inflation at birth. J. Exp. Med., 211: 815-826. [pdf]
  81. Siedlik M.J. & Nelson C.M. (2014) Mechanics of tissue morphogenesis. In Cell and Matrix Mechanics (eds. Zemel A. & Kaunas R.), in press.
  80. Varner V.D. & Nelson C.M. (2014) Toward the directed self-assembly of engineered tissues. Annu. Rev. Chem. Biomol. Eng., 5: 507-526. [pdf]
  79. Tien J. & Nelson C.M. (2014) Microstructured extracellular matrices in tissue engineering and development, an update. Ann. Biomed. Eng., 42: 1413-1423. [pdf]
  78. Kim H.Y. & Nelson C.M. (2014) Epithelial engineering: from sheets to branched tubes. In Bio-Inspired Materials for Biomedical Engineering (eds. Kirscher C.M. & Brennan A.B.), in press.
  77. Piotrowski A., Varner V.D., Gjorevski N., & Nelson C.M. (2014) Three-dimensional traction force microscopy of engineered epithelial tissues. In Tissue Morphogenesis (Methods in Molecular Biology series) (ed. Nelson C.M.) (Springer, New York), in press.
  76. Nelson C.M. (2013) Forces in epithelial origami. Dev. Cell, 26: 554-556. [pdf]
  75. Varner V.D. & Nelson C.M. (2013) Let's push things forward: disruptive technologies and the mechanics of tissue assembly. Integr. Biol., 5: 1162-1173. [pdf]
  74. Kim H.Y., Varner V.D., & Nelson C.M. (2013) Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. Development, 140: 3146-3155. [pdf] [supp]
  73. Zhu W. & Nelson C.M. (2013) PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. Dev. Biol., 379: 235-245. [pdf]
  72. Radisky D.C. & Nelson C.M. (2013) Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget, 4: 498-499. [pdf]
  71. Gleghorn J.P., Manivannan S., & Nelson C.M. (2013) Quantitative approaches to uncover physical mechanisms of morphogenesis. Curr. Opin. Biotechnol., 24: 954-961. [pdf]
  70. Zhu W. & Nelson C.M. (2013) Adipose and mammary epithelial tissue engineering. Biomatter, 3: e24630. [pdf]
  69. Chen Q.K., Lee K., Radisky D.C., & Nelson C.M. (2013) Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation, 86: 126-132.
  68. Lee K. & Nelson C.M. (2013) Determining the role of matrix compliance in the differentiation of mammary stem cells. In Biomimetics and Stem Cells: Methods and Protocols (Methods in Molecular Biology series) (eds. Vunjak-Novakovic G., Turksen K.) (Springer, New York), in press. [pdf]
  67. Mori H., Lo A.T., Ghajar C.M., Inman J.L., Alcaraz J., Chen C.S., Nelson C.M., Zhang H., Mott J.D., Bascom J.L., Seiki M., & Bissell M.J. (2013) Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1. Development, 140: 343-352. [pdf][supp]
  66. Boghaert E., Gleghorn J.P., Lee K., Gjorevski N., Radisky D.C., & Nelson C.M. (2012) Host epithelial geometry regulates breast cancer cell invasiveness. Proc. Natl. Acad. Sci. USA, 109: 19362-19367. [pdf][supp]
  65. Nelson C.M. (2012) Symmetry breaking during morphogenesis in the embryo and in engineered tissues. AIChE J., 58: 3608-3613. [pdf][cover]
  64. Tien J., Truslow J.G., & Nelson C.M. (2012) Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells. PLOS ONE, 7: e45191. [pdf]
  63. Lee K., Chen Q.K., Lui C., Cichon M.A., Radisky D.C., & Nelson C.M. (2012) Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol. Biol. Cell, 23: 4097-4108. [pdf][supp][cover]
  62. Manivannan S. & Nelson C.M. (2012) Dynamics of branched tissue assembly. Stem Cell Res. Ther., 3: 42. [pdf]
  61. Gjorevski N. & Nelson C.M. (2012) Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. Biophys. J., 103: 152-162. [pdf][supp]
  60. Zhu W. & Nelson C.M. (2012) PI3K signaling in the regulation of branching morphogenesis. BioSystems, 109: 403-411. [pdf]
  59. Gleghorn J.P., Kwak J., Pavlovich A.L., & Nelson C.M. (2012) Inhibitory morphogens and monopodial branching of the embryonic chicken lung. Dev. Dyn., 241: 852-862. [pdf]
  58. Kim H.Y. & Nelson C.M. (2012) Extracellular matrix and cytoskeletal dynamics during branching morphogenesis. Organogenesis, 8: 56-64. [pdf]
  57. Chung J.W., Lee K., Neikirk C., Nelson C.M., & Priestley R.D. (2012) Photo-responsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier. Small, 8: 1693-1700. [pdf]
  56. Nelson C.M. & Gleghorn J.P. (2012) Sculpting organs: Mechanical regulation of tissue development. Annu. Rev. Biomed. Eng., 14: 129-154. [pdf]
  55. Nelson C.M. (2012) Bioengineering and mechanobiology: pushing (and pulling) the limits of cellular mechanics. Mol. Biol. Cell, 23: 969. [pdf]
  54. Lui C., Lee K., & Nelson C.M. (2012) Matrix compliance and RhoA direct the differentiation of mammary progenitor cells. Biomech. Model. Mechanobiol., 11: 1241-1249. [pdf]
  53. Gjorevski N., Boghaert E., & Nelson C.M. (2012) Regulation of epithelial-mesenchymal transition by transmission of mechanical stress through epithelial tissues. Cancer Microenvironment, 5: 29-38. [pdf]
  52. Gleghorn J.P. & Nelson C.M. (2012) Nanopatterned surfaces for exploring and regulating cell behavior. Encyclopedia Nanotech., (ed. Bhushan B.) (Springer, New York), pp. 1670-1678. [pdf]
  51. Manivannan S., Gleghorn J.P., & Nelson C.M. (2012) Engineered tissues to quantify collective cell migration during morphogenesis. In Kidney Development: Methods and Protocols (Methods in Molecular Biology vol. 886) (ed. Michos O.) (Springer, New York), pp. 173-182. [pdf]
  50. Cung K., Slater R.L., Cui Y., Manivannan S., Jones S.E., Ahmad H., Nelson C.M., Naik R.R., & McAlpine M.C. (2012) Rapid, multiplexed microfluidic phage display. Lab Chip, 12: 562-565. [pdf]
  49. Lee K. & Nelson C.M. (2012) New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int. Rev. Cell Mol. Biol., 294: 169-219. [pdf]
  48. Gjorevski N. & Nelson C.M. (2011) Integrated morphodynamic signalling of the mammary gland. Nat. Rev. Mol. Cell Biol., 12: 581-593. [pdf]
  47. Lee K., Gjorevski N., Boghaert E., Radisky D.C., & Nelson C.M. (2011) Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. EMBO J., 30: 2662-2674. [pdf][supp]
  46. Pavlovich A.L., Boghaert E., & Nelson C.M. (2011) Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFbeta in culture. Exp. Cell Res., 317: 1872-1884. [pdf]
  45. Gomez E.W. & Nelson C.M. (2011) Lithographically-defined two- and three-dimensional tissue microarrays. In Biological Microarrays (Methods in Molecular Biology, vol. 671) pp. 107-116 (eds. Khademhosseini A., Suh K.-Y., & Zourob M.) (Springer, New York). [pdf]
  44. Raghavan S., Shen C.J., Desai R.A., Sniadecki N.J., Nelson C.M., & Chen C.S. (2010) Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. J. Cell Sci., 123: 2877-2883. [pdf]
  43. Gjorevski N. & Nelson C.M. (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Integr. Biol., 2: 424-434. [pdf][supp]
  42. Pavlovich A.L., Manivannan S., & Nelson C.M. (2010) Adipose stroma induces branching morphogenesis of engineered epithelial tubules. Tissue Eng. Part A, 16: 3719-3726. [pdf]
  41. Boghaert E. & Nelson C.M. (2010) Tumor microenvironment and host/stroma interactions: Guidelines for physical modeling. in Biophysical Modeling of Cancer in Silico (ed. Cristini V.), in press (Springer, New York).
  40. Gjorevski N. & Nelson C.M. (2010) The mechanics of development: models and methods for tissue morphogenesis. Birth Defects Res. C Embryo Today, 90: 193-202. [pdf]
  39. Liu Z., Tan J.L., Cohen D.M., Yang M.T., Sniadecki N.J., Ruiz S.A., Nelson C.M., & Chen C.S. (2010) Mechanical tugging forces regulate the size of cell-cell junctions. Proc. Natl. Acad. Sci. USA, 107: 9944-9949. [pdf][supp]
  38. Raghavan S., Nelson C.M., Baranski J.D., Lim E., & Chen C.S. (2010) Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng. Part A, 16: 2255-2263. [pdf]
  37. Gjorevski N. & Nelson C.M. (2010) Branch formation during organ development. Wiley Interdiscip. Rev. Systems Biol. Med., 2: 734-741. [pdf]
  36. Gomez E.W., Chen Q.K., Gjorevski N., & Nelson C.M. (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J. Cell. Biochem., 110: 44-51. [pdf][supp][cover]
  35. Mori H., Gjorevski N., Inman J.L., Bissell M.J., & Nelson C.M. (2009) Self-organization of engineered epithelial tubules by differential cellular motility. Proc. Natl. Acad. Sci. USA, 106: 14890-14895. [pdf][supp]
  34. Gjorevski N. & Nelson C.M. (2009) Bidirectional extracellular matrix signaling during tissue morphogenesis. Cytokine Growth Factor Rev., 20: 459-465. [pdf]
  33. Chen C.S., Nelson C.M., Khauv D., Bennett S., Radisky E.S., Hirai Y., Bissell M.J., & Radisky D.C. (2009) Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J. Biol. Chem., 284: 6877-6884. [pdf][cover]
  32. Nelson C.M. (2009) Geometric control of tissue morphogenesis. Biochim. Biophys. Acta, 1793: 903-910. [pdf]
  31. LaBarge M.A., Nelson C.M., Villadsen R., Fridriksdottir A., Ruth J.R., Stampfer M.R., Petersen O.W., & Bissell M.J. (2009) Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol., 1: 70-79. [pdf][cover]
  30. Xu R., Nelson C.M., Muschler J.L., Vonderhaar B.K., & Bissell M.J. (2009) Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biol., 184: 57-66. [pdf]
  29. Alcaraz J., Xu R., Mori H., Nelson C.M., Mroue R., Spencer V.A., Brownfield D., Radisky D.C., Bustamante C., & Bissell M.J. (2008) Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J., 27: 2829-2838. [pdf]
  28. Gray D.S., Liu W.F., Shen C.J., Bhadriraju K., Nelson C.M., & Chen C.S. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp. Cell. Res., 314: 2846-2854. [pdf]
  27. Nelson C.M., Khauv D., Bissell M.J., & Radisky D.C. (2008) Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J. Cell. Biochem., 105: 25-33. [pdf][cover]
  26. Nelson C.M., Inman J.L., & Bissell M.J. (2008) Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat. Protoc., 3: 674-678. [pdf]
  25. Liu W.F., Nelson C.M., Tan J.L., & Chen C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ. Res., 101: e44-52. [pdf]
  24. Hirai Y., Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., & Radisky D.C. (2007) The non-classical export of epimorphin and its adhesion to alpha-v-integrin for regulation of epithelial morphogenesis. J. Cell Sci., 120: 2032-2043. [pdf]
  23. LeBeyec J., Xu R., MoonLee S.Y., Nelson C.M., Rizki A., Alcaraz J., & Bissell M.J. (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp. Cell Res., 313: 3066-3075. [pdf]
  22. Itoh M., Nelson C.M., Myers C.A., & Bissell M.J. (2007) Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res., 67: 4759-4766. [pdf][cover]
  21. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., & Bissell M.J. (2006) Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science, 314: 298-300. [pdf][supp]
  20. Nelson C.M. & Tien J. (2006) Microstructured extracellular matrices in tissue engineering and development. Curr. Opin. Biotech., 17: 518-523. [pdf]
 

19. Liu W.F., Nelson C.M., Pirone D.M., & Chen C.S. (2006) E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol., 173: 431-441. [pdf][supp]

  18. Nelson C.M. & Bissell M.J. (2006) Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol., 22: 287-309. [pdf]
  17. Kenny P.A., Nelson C.M., & Bissell M.J. (2006) The ecology of tumors. The Scientist, April: 30-37. [pdf]
  16. Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., & Bissell M.J. (2006) Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. USA, 103: 4134-4139. [pdf][supp]
  15. Nelson C.M., Liu W.F., & Chen C.S. (2006) Manipulation of cell-cell adhesion using bowtie-shaped microwells. Adhesion Protein Protocols (Methods in Molecular Biology, Vol. 96), 1-10. [pdf]
  14. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., & Chen C.S. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA, 102: 11594-11599. [pdf][supp]
  13. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., & Bissell M.J. (2005) Rac1b and reactive oxygen species mediate MMP3-induced EMT and genomic instability. Nature, 436: 123-127. [pdf]
  12. Nelson C.M, & Bissell M.J. (2005) Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol., 15: 342-352. [pdf]
  11. Alcaraz J., Nelson C.M., & Bissell M.J. (2004) Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J. Mammary Gland Biol. Neoplasia, 9: 361-374. [pdf]
  10. Tan J.L., Liu W., Nelson C.M., Raghavan S., & Chen C.S. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng., 10: 865-872. [pdf]
  9. Nelson C.M., Pirone D.M., Tan J.L., & Chen C.S. (2004) Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol. Biol. Cell, 15: 2943-2953. [pdf][supp]
  8. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., & Chen C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell, 6: 483-495. [pdf]
  7. Nelson C.M. & Chen C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell Sci., 116: 3571-3581. [pdf][cover]
  6. Nelson C.M. & Chen C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem. Eng. Tech., in press. [pdf]
  5. Nelson C.M., Raghavan S., Tan J.L., & Chen C.S. (2003) Degradation of micropatterned surfaces by cell-dependent and -independent processes. Langmuir, 19: 1493-1499. [pdf]
 

4. Tan J.L., Nelson C.M., Gray D.S., & Chen C.S. (2002) Approaches to organize cells on surfaces. IEEE Engineering in Medicine and Biology Magazine, 101-103. [pdf]

  3. Nelson C.M. & Chen C.S. (2002) Cell-cell contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters, 514: 238-242. [pdf]
  2. Tien J., Nelson C.M., & Chen C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc. Natl. Acad. Sci. USA, 99: 1758-1762. [pdf][cover]
  1. Asthagiri A.R., Nelson C.M., Horwitz A.F., & Lauffenburger D.A. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular-signal regulated kinase 2. J. Biol. Chem., 274: 27119-27127. [pdf]

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