TISSUE MORPHODYNAMICS LABORATORY
Publications
Please note: Reprints are provided for personal use only.
  36. Mori H., Gjorevski N., Inman J.L., Bissell M.J., & Nelson C.M. (2009) Self-organization of engineered epithelial tubules by differential cellular motility. Proc. Natl. Acad. Sci. USA, in press. [pdf] [supp]
  35. Gjorevski N. & Nelson C.M. (2009) Bidirectional extracellular matrix signaling during tissue morphogenesis. Cytokine Growth Factor Rev., in press. [pdf]
  34. Gomez E.W. & Nelson C.M. (2009) Lithographically-defined two- and three-dimensional tissue microarrays. Biological Microarrays (Methods in Molecular Biology), in press.
  33. Chen C.S., Nelson C.M., Khauv D., Bennett S., Radisky E.S., Hirai Y., Bissell M.J., & Radisky D.C. (2009) Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J. Biol. Chem., 284: 6877-6884. [pdf] [cover]
  32. Nelson C.M. (2009) Geometric control of tissue morphogenesis. Biochim. Biophys. Acta, 1793: 903-910. [pdf]
  31. LaBarge M.A., Nelson C.M., Villadsen R., Fridriksdottir A., Ruth J.R., Stampfer M.R., Petersen O.W., & Bissell M.J. (2009) Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol., 1: 70-79. [pdf] [cover]
  30. Xu R., Nelson C.M., Muschler J.L., Vonderhaar B.K., & Bissell M.J. (2009) Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biol., 184: 57-66. [pdf]
  29. Alcaraz J., Xu R., Mori H., Nelson C.M., Mroue R., Spencer V.A., Brownfield D., Radisky D.C., Bustamante C., & Bissell M.J. (2008) Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J., 27: 2829-2838. [pdf]
  28. Gray D.S., Liu W.F., Shen C.J., Bhadriraju K., Nelson C.M., & Chen C.S. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp. Cell. Res., 314: 2846-2854. [pdf]
  27. Nelson C.M., Khauv D., Bissell M.J., & Radisky D.C. (2008) Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J. Cell. Biochem., 105: 25-33. [pdf] [cover]
  26. Nelson C.M., Inman J.L., & Bissell M.J. (2008) Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat. Protoc., 3: 674-678. [pdf]
  25. Liu W.F., Nelson C.M., Tan J.L., & Chen C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ. Res., 101: e44-52. [pdf]
  24. Hirai Y., Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., & Radisky D.C. (2007) The non-classical export of epimorphin and its adhesion to alpha-v-integrin for regulation of epithelial morphogenesis. J. Cell Sci., 120: 2032-2043. [pdf]
  23. LeBeyec J., Xu R., MoonLee S.Y., Nelson C.M., Rizki A., Alcaraz J., & Bissell M.J. (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp. Cell Res., 313: 3066-3075. [pdf]
  22. Itoh M., Nelson C.M., Myers C.A., & Bissell M.J. (2007) Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res., 67: 4759-4766. [pdf] [cover]
  21. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., & Bissell M.J. (2006) Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science, 314: 298-300. [pdf] [supp]
  20. Nelson C.M. & Tien J. (2006) Microstructured extracellular matrices in tissue engineering and development. Curr. Opin. Biotech., 17: 518-523. [pdf]
 

19. Liu W.F., Nelson C.M., Pirone D.M., & Chen C.S. (2006) E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol., 173: 431-441. [pdf] [supp]

  18. Nelson C.M. & Bissell M.J. (2006) Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol., 22: 287-309. [pdf]
  17. Kenny P.A., Nelson C.M., & Bissell M.J. (2006) The ecology of tumors. The Scientist, April: 30-37. [pdf]
  16. Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., & Bissell M.J. (2006) Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. USA, 103: 4134-4139. [pdf] [supp]
  15. Nelson C.M., Liu W.F., & Chen C.S. (2006) Analysis of cell-cell adhesion by bowtie-shaped microwells. Adhesion Protein Protocols (Methods in Molecular Biology, Vol. 96), 1-10. [pdf]
  14. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., & Chen C.S. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA, 102: 11594-11599. [pdf] [supp]
  13. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., & Bissell M.J. (2005) Rac1b and reactive oxygen species mediate MMP3-induced EMT and genomic instability. Nature, 436: 123-127. [pdf]
  12. Nelson C.M, & Bissell M.J. (2005) Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol., 15: 342-352. [pdf]
  11. Alcaraz J., Nelson C.M., & Bissell M.J. (2004) Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J. Mammary Gland Biol. Neoplasia, 9: 361-374. [pdf]
  10. Tan J.L., Liu W., Nelson C.M., Raghavan S., & Chen C.S. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng., 10: 865-872. [pdf]
  9. Nelson C.M., Pirone D.M., Tan J.L., & Chen C.S. (2004) Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol. Biol. Cell, 15: 2943-2953. [pdf] [supp]
  8. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., & Chen C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell, 6: 483-495. [pdf]
  7. Nelson C.M. & Chen C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell Sci., 116: 3571-3581. [pdf] [cover]
  6. Nelson C.M. & Chen C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem. Eng. Tech., in press. [pdf]
  5. Nelson C.M., Raghavan S., Tan J.L., & Chen C.S. (2003) Degradation of micropatterned surfaces by cell-dependent and -independent processes. Langmuir, 19: 1493-1499. [pdf]
 

4. Tan J.L., Nelson C.M., Gray D.S., & Chen C.S. (2002) Approaches to organize cells on surfaces. IEEE Engineering in Medicine and Biology Magazine, 101-103. [pdf]
  3. Nelson C.M. & Chen C.S. (2002) Cell-cell contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters, 514: 238-242. [pdf]
  2. Tien J., Nelson C.M., & Chen C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc. Natl. Acad. Sci. USA, 99: 1758-1762. [pdf] [cover]
  1. Asthagiri A.R., Nelson C.M., Horwitz A.F., & Lauffenburger D.A. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular-signal regulated kinase 2. J. Biol. Chem., 274: 27119-27127. [pdf]

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