TISSUE MORPHODYNAMICS LABORATORY
 
Publications
Please note: Reprints are provided for personal use only.
  86. Piotrowski A.S., Simi A.K., Pang M.F., Tien J., & Nelson C.M. (2014) A three-dimensional culture model to study how fluid pressure and flow affect the behavior of aggregates of epithelial cells. In Mammary Gland Development (Methods in Molecular Biology series) (eds. Martin F. & Stein T.), in press.
  85. Simi A.K., Piotrowski A.S., & Nelson C.M. (2014) Mechanotransduction, metastasis, and genomic instability. In Genomic instability and DNA repair in cancer progression and metastasis (eds. Maxwell C. & Roskelley C.), in press.
  84. Varner V.D. & Nelson C.M. (2014) Cellular and physical mechanisms of branching morphogenesis. Development, 141: 2750-2759. [pdf]
  83. Schawrz U., Nelson C.M., & Silberzan P. (2014) Proteins, cells, and tissues in patterned environments. Soft Matter, 10: 2337-2340. [pdf]
  82. Jakus Z., Gleghorn J.P., Enis D., Sen A., Chia S., Liu X., Rawnsley D., Yang Y., Hess P., Zou Z., Yang J., Guttentag S., Nelson C.M., & Kahn M.L. (2014) Lymphatic vascular function is required perinatally for lung inflation at birth. J. Exp. Med., 211: 815-826. [pdf]
  81. Siedlik M.J. & Nelson C.M. (2014) Mechanics of tissue morphogenesis. In Cell and Matrix Mechanics (eds. Zemel A. & Kaunas R.), CRC Press, 285-308.
  80. Varner V.D. & Nelson C.M. (2014) Toward the directed self-assembly of engineered tissues. Annu. Rev. Chem. Biomol. Eng., 5: 507-526. [pdf]
  79. Tien J. & Nelson C.M. (2014) Microstructured extracellular matrices in tissue engineering and development, an update. Ann. Biomed. Eng., 42: 1413-1423. [pdf]
  78. Kim H.Y. & Nelson C.M. (2014) Epithelial engineering: from sheets to branched tubes. In Bio-Inspired Materials for Biomedical Engineering (eds. Kirscher C.M. & Brennan A.B.), 161-173.
  77. Piotrowski A., Varner V.D., Gjorevski N., & Nelson C.M. (2014) Three-dimensional traction force microscopy of engineered epithelial tissues. In Tissue Morphogenesis (Methods in Molecular Biology series) (ed. Nelson C.M.) (Springer, New York), 1189: 191-207.
  76. Lee K. & Nelson C.M. (2014) Determining the role of matrix compliance in the differentiation of mammary stem cells. In Biomimetics and Stem Cells: Methods and Protocols (Methods in Molecular Biology series) (eds. Vunjak-Novakovic G., Turksen K.) (Springer, New York), 1202: 79-94. [pdf]
  75. Nelson C.M. (2013) Forces in epithelial origami. Dev. Cell, 26: 554-556. [pdf]
  74. Varner V.D. & Nelson C.M. (2013) Let's push things forward: disruptive technologies and the mechanics of tissue assembly. Integr. Biol., 5: 1162-1173. [pdf]
  73. Kim H.Y., Varner V.D., & Nelson C.M. (2013) Apical constriction initiates new bud formation during monopodial branching of the embryonic chicken lung. Development, 140: 3146-3155. [pdf] [supp]
  72. Zhu W. & Nelson C.M. (2013) PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. Dev. Biol., 379: 235-245. [pdf]
  71. Radisky D.C. & Nelson C.M. (2013) Regulation of mechanical stress by mammary epithelial tissue structure controls breast cancer cell invasion. Oncotarget, 4: 498-499. [pdf]
  70. Gleghorn J.P., Manivannan S., & Nelson C.M. (2013) Quantitative approaches to uncover physical mechanisms of morphogenesis. Curr. Opin. Biotechnol., 24: 954-961. [pdf]
  69. Zhu W. & Nelson C.M. (2013) Adipose and mammary epithelial tissue engineering. Biomatter, 3: e24630. [pdf]
  68. Chen Q.K., Lee K., Radisky D.C., & Nelson C.M. (2013) Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. Differentiation, 86: 126-132.
  67. Mori H., Lo A.T., Ghajar C.M., Inman J.L., Alcaraz J., Chen C.S., Nelson C.M., Zhang H., Mott J.D., Bascom J.L., Seiki M., & Bissell M.J. (2013) Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin beta1. Development, 140: 343-352. [pdf][supp]
  66. Boghaert E., Gleghorn J.P., Lee K., Gjorevski N., Radisky D.C., & Nelson C.M. (2012) Host epithelial geometry regulates breast cancer cell invasiveness. Proc. Natl. Acad. Sci. USA, 109: 19362-19367. [pdf][supp]
  65. Nelson C.M. (2012) Symmetry breaking during morphogenesis in the embryo and in engineered tissues. AIChE J., 58: 3608-3613. [pdf][cover]
  64. Tien J., Truslow J.G., & Nelson C.M. (2012) Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells. PLOS ONE, 7: e45191. [pdf]
  63. Lee K., Chen Q.K., Lui C., Cichon M.A., Radisky D.C., & Nelson C.M. (2012) Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol. Biol. Cell, 23: 4097-4108. [pdf][supp][cover]
  62. Manivannan S. & Nelson C.M. (2012) Dynamics of branched tissue assembly. Stem Cell Res. Ther., 3: 42. [pdf]
  61. Gjorevski N. & Nelson C.M. (2012) Mapping of mechanical strains and stresses around quiescent engineered three-dimensional epithelial tissues. Biophys. J., 103: 152-162. [pdf][supp]
  60. Zhu W. & Nelson C.M. (2012) PI3K signaling in the regulation of branching morphogenesis. BioSystems, 109: 403-411. [pdf]
  59. Gleghorn J.P., Kwak J., Pavlovich A.L., & Nelson C.M. (2012) Inhibitory morphogens and monopodial branching of the embryonic chicken lung. Dev. Dyn., 241: 852-862. [pdf]
  58. Kim H.Y. & Nelson C.M. (2012) Extracellular matrix and cytoskeletal dynamics during branching morphogenesis. Organogenesis, 8: 56-64. [pdf]
  57. Chung J.W., Lee K., Neikirk C., Nelson C.M., & Priestley R.D. (2012) Photo-responsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier. Small, 8: 1693-1700. [pdf]
  56. Nelson C.M. & Gleghorn J.P. (2012) Sculpting organs: Mechanical regulation of tissue development. Annu. Rev. Biomed. Eng., 14: 129-154. [pdf]
  55. Nelson C.M. (2012) Bioengineering and mechanobiology: pushing (and pulling) the limits of cellular mechanics. Mol. Biol. Cell, 23: 969. [pdf]
  54. Lui C., Lee K., & Nelson C.M. (2012) Matrix compliance and RhoA direct the differentiation of mammary progenitor cells. Biomech. Model. Mechanobiol., 11: 1241-1249. [pdf]
  53. Gjorevski N., Boghaert E., & Nelson C.M. (2012) Regulation of epithelial-mesenchymal transition by transmission of mechanical stress through epithelial tissues. Cancer Microenvironment, 5: 29-38. [pdf]
  52. Gleghorn J.P. & Nelson C.M. (2012) Nanopatterned surfaces for exploring and regulating cell behavior. Encyclopedia Nanotech., (ed. Bhushan B.) (Springer, New York), pp. 1670-1678. [pdf]
  51. Manivannan S., Gleghorn J.P., & Nelson C.M. (2012) Engineered tissues to quantify collective cell migration during morphogenesis. In Kidney Development: Methods and Protocols (Methods in Molecular Biology vol. 886) (ed. Michos O.) (Springer, New York), pp. 173-182. [pdf]
  50. Cung K., Slater R.L., Cui Y., Manivannan S., Jones S.E., Ahmad H., Nelson C.M., Naik R.R., & McAlpine M.C. (2012) Rapid, multiplexed microfluidic phage display. Lab Chip, 12: 562-565. [pdf]
  49. Lee K. & Nelson C.M. (2012) New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int. Rev. Cell Mol. Biol., 294: 169-219. [pdf]
  48. Gjorevski N. & Nelson C.M. (2011) Integrated morphodynamic signalling of the mammary gland. Nat. Rev. Mol. Cell Biol., 12: 581-593. [pdf]
  47. Lee K., Gjorevski N., Boghaert E., Radisky D.C., & Nelson C.M. (2011) Snail1, Snail2, and E47 promote mammary epithelial branching morphogenesis. EMBO J., 30: 2662-2674. [pdf][supp]
  46. Pavlovich A.L., Boghaert E., & Nelson C.M. (2011) Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFbeta in culture. Exp. Cell Res., 317: 1872-1884. [pdf]
  45. Gomez E.W. & Nelson C.M. (2011) Lithographically-defined two- and three-dimensional tissue microarrays. In Biological Microarrays (Methods in Molecular Biology, vol. 671) pp. 107-116 (eds. Khademhosseini A., Suh K.-Y., & Zourob M.) (Springer, New York). [pdf]
  44. Raghavan S., Shen C.J., Desai R.A., Sniadecki N.J., Nelson C.M., & Chen C.S. (2010) Decoupling diffusional from dimensional control of signaling in 3D culture reveals a role for myosin in tubulogenesis. J. Cell Sci., 123: 2877-2883. [pdf]
  43. Gjorevski N. & Nelson C.M. (2010) Endogenous patterns of mechanical stress are required for branching morphogenesis. Integr. Biol., 2: 424-434. [pdf][supp]
  42. Pavlovich A.L., Manivannan S., & Nelson C.M. (2010) Adipose stroma induces branching morphogenesis of engineered epithelial tubules. Tissue Eng. Part A, 16: 3719-3726. [pdf]
  41. Boghaert E. & Nelson C.M. (2010) Tumor microenvironment and host/stroma interactions: Guidelines for physical modeling. in Biophysical Modeling of Cancer in Silico (ed. Cristini V.), in press (Springer, New York).
  40. Gjorevski N. & Nelson C.M. (2010) The mechanics of development: models and methods for tissue morphogenesis. Birth Defects Res. C Embryo Today, 90: 193-202. [pdf]
  39. Liu Z., Tan J.L., Cohen D.M., Yang M.T., Sniadecki N.J., Ruiz S.A., Nelson C.M., & Chen C.S. (2010) Mechanical tugging forces regulate the size of cell-cell junctions. Proc. Natl. Acad. Sci. USA, 107: 9944-9949. [pdf][supp]
  38. Raghavan S., Nelson C.M., Baranski J.D., Lim E., & Chen C.S. (2010) Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng. Part A, 16: 2255-2263. [pdf]
  37. Gjorevski N. & Nelson C.M. (2010) Branch formation during organ development. Wiley Interdiscip. Rev. Systems Biol. Med., 2: 734-741. [pdf]
  36. Gomez E.W., Chen Q.K., Gjorevski N., & Nelson C.M. (2010) Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J. Cell. Biochem., 110: 44-51. [pdf][supp][cover]
  35. Mori H., Gjorevski N., Inman J.L., Bissell M.J., & Nelson C.M. (2009) Self-organization of engineered epithelial tubules by differential cellular motility. Proc. Natl. Acad. Sci. USA, 106: 14890-14895. [pdf][supp]
  34. Gjorevski N. & Nelson C.M. (2009) Bidirectional extracellular matrix signaling during tissue morphogenesis. Cytokine Growth Factor Rev., 20: 459-465. [pdf]
  33. Chen C.S., Nelson C.M., Khauv D., Bennett S., Radisky E.S., Hirai Y., Bissell M.J., & Radisky D.C. (2009) Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J. Biol. Chem., 284: 6877-6884. [pdf][cover]
  32. Nelson C.M. (2009) Geometric control of tissue morphogenesis. Biochim. Biophys. Acta, 1793: 903-910. [pdf]
  31. LaBarge M.A., Nelson C.M., Villadsen R., Fridriksdottir A., Ruth J.R., Stampfer M.R., Petersen O.W., & Bissell M.J. (2009) Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr. Biol., 1: 70-79. [pdf][cover]
  30. Xu R., Nelson C.M., Muschler J.L., Vonderhaar B.K., & Bissell M.J. (2009) Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J. Cell Biol., 184: 57-66. [pdf]
  29. Alcaraz J., Xu R., Mori H., Nelson C.M., Mroue R., Spencer V.A., Brownfield D., Radisky D.C., Bustamante C., & Bissell M.J. (2008) Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J., 27: 2829-2838. [pdf]
  28. Gray D.S., Liu W.F., Shen C.J., Bhadriraju K., Nelson C.M., & Chen C.S. (2008) Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Exp. Cell. Res., 314: 2846-2854. [pdf]
  27. Nelson C.M., Khauv D., Bissell M.J., & Radisky D.C. (2008) Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J. Cell. Biochem., 105: 25-33. [pdf][cover]
  26. Nelson C.M., Inman J.L., & Bissell M.J. (2008) Three-dimensional lithographically-defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat. Protoc., 3: 674-678. [pdf]
  25. Liu W.F., Nelson C.M., Tan J.L., & Chen C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ. Res., 101: e44-52. [pdf]
  24. Hirai Y., Nelson C.M., Yamazaki K., Takebe K., Przybylo J., Madden B., & Radisky D.C. (2007) The non-classical export of epimorphin and its adhesion to alpha-v-integrin for regulation of epithelial morphogenesis. J. Cell Sci., 120: 2032-2043. [pdf]
  23. LeBeyec J., Xu R., MoonLee S.Y., Nelson C.M., Rizki A., Alcaraz J., & Bissell M.J. (2007) Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp. Cell Res., 313: 3066-3075. [pdf]
  22. Itoh M., Nelson C.M., Myers C.A., & Bissell M.J. (2007) Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res., 67: 4759-4766. [pdf][cover]
  21. Nelson C.M., VanDuijn M.M., Inman J.L., Fletcher D.A., & Bissell M.J. (2006) Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science, 314: 298-300. [pdf][supp]
  20. Nelson C.M. & Tien J. (2006) Microstructured extracellular matrices in tissue engineering and development. Curr. Opin. Biotech., 17: 518-523. [pdf]
 

19. Liu W.F., Nelson C.M., Pirone D.M., & Chen C.S. (2006) E-cadherin engagement stimulates proliferation via Rac1. J. Cell Biol., 173: 431-441. [pdf][supp]

  18. Nelson C.M. & Bissell M.J. (2006) Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell Dev. Biol., 22: 287-309. [pdf]
  17. Kenny P.A., Nelson C.M., & Bissell M.J. (2006) The ecology of tumors. The Scientist, April: 30-37. [pdf]
  16. Liu H., Radisky D.C., Nelson C.M., Zhang H., Fata J.E., Roth R.A., & Bissell M.J. (2006) Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc. Natl. Acad. Sci. USA, 103: 4134-4139. [pdf][supp]
  15. Nelson C.M., Liu W.F., & Chen C.S. (2006) Manipulation of cell-cell adhesion using bowtie-shaped microwells. Adhesion Protein Protocols (Methods in Molecular Biology, Vol. 96), 1-10. [pdf]
  14. Nelson C.M., Jean R.P., Tan J.L., Liu W.F., Sniadecki N.J., Spector A.A., & Chen C.S. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc. Natl. Acad. Sci. USA, 102: 11594-11599. [pdf][supp]
  13. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., & Bissell M.J. (2005) Rac1b and reactive oxygen species mediate MMP3-induced EMT and genomic instability. Nature, 436: 123-127. [pdf]
  12. Nelson C.M, & Bissell M.J. (2005) Modeling dynamic reciprocity: Engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin. Cancer Biol., 15: 342-352. [pdf]
  11. Alcaraz J., Nelson C.M., & Bissell M.J. (2004) Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J. Mammary Gland Biol. Neoplasia, 9: 361-374. [pdf]
  10. Tan J.L., Liu W., Nelson C.M., Raghavan S., & Chen C.S. (2004) Simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Eng., 10: 865-872. [pdf]
  9. Nelson C.M., Pirone D.M., Tan J.L., & Chen C.S. (2004) Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA. Mol. Biol. Cell, 15: 2943-2953. [pdf][supp]
  8. McBeath R., Pirone D.M., Nelson C.M., Bhadriraju K., & Chen C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell, 6: 483-495. [pdf]
  7. Nelson C.M. & Chen C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J. Cell Sci., 116: 3571-3581. [pdf][cover]
  6. Nelson C.M. & Chen C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem. Eng. Tech., in press. [pdf]
  5. Nelson C.M., Raghavan S., Tan J.L., & Chen C.S. (2003) Degradation of micropatterned surfaces by cell-dependent and -independent processes. Langmuir, 19: 1493-1499. [pdf]
 

4. Tan J.L., Nelson C.M., Gray D.S., & Chen C.S. (2002) Approaches to organize cells on surfaces. IEEE Engineering in Medicine and Biology Magazine, 101-103. [pdf]

  3. Nelson C.M. & Chen C.S. (2002) Cell-cell contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters, 514: 238-242. [pdf]
  2. Tien J., Nelson C.M., & Chen C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc. Natl. Acad. Sci. USA, 99: 1758-1762. [pdf][cover]
  1. Asthagiri A.R., Nelson C.M., Horwitz A.F., & Lauffenburger D.A. (1999) Quantitative relationship among integrin-ligand binding, adhesion, and signaling via focal adhesion kinase and extracellular-signal regulated kinase 2. J. Biol. Chem., 274: 27119-27127. [pdf]

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