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Selected Publications “A Hypervalent
Iodine-Induced Double Annulation Enables a Concise
Synthesis of the Pentacyclic Core Structure of the Cortistatins”, J. L. Frie, C. S.
Jeffrey, and E. J. Sorensen, Org. Lett.,
2009,
ASAP.
(click here for PDF) “Bond
formations by intermolecular and intramolecular
trappings of acylketenes and their applications in
natural product synthesis”, K.
P. Reber, S. D. Tilley and E. J. Sorensen,
Chem.
Soc. Rev., 2009, 38, 3022-3034 . (click here for PDF) "A
Nature-Inspired Diels-Alder Reaction Facilitates
Construction of the Bicyclo[2.2.2]octane Core of Andibenin
B", J. E. Spangler, E. J.
Sorensen,
Tetrahedron, 2009,
65, 6739-6745. (click here for PDF) "A Rapid, Asymmetric Synthesis of the Decahydrofluorene Core of the Hirsutellones", S. D. Tilley, K. P. Reber and E. J. Sorensen, Org. Lett. 2009, 11, 701-703. (click here for PDF) "An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles", J. S. Schneekloth, Jr., J. Kim and E. J. Sorensen, Tetrahedron. 2009, 65, 3096–3101. (click here for PDF) "A synthesis of the tricyclic core structure of FR901483 featuring an Ugi four-component coupling and a remarkably selective elimination reaction", H. Seike, E. J. Sorensen, Synlett. 2008, 5, 695-701. (click here for PDF) "Classical carbonyl reactivity enables a short synthesis of the core structure of acutumine", R. J. Moreau, E. J. Sorensen, Tetrahedron. 2007, 63, 6446-6453. (click here for PDF) "Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites", R. M. Buey, E. Calvo, I. Barasoain, O. Pineda, M. C. Edler, R. Matesanz, G. Cerezo, C. D. Vanderwal, B. W. Day, E. J. Sorensen, J. A. Lopez, J. M. Andreu, E. Hamel, J. F. Diaz, Nat. Chem. Biol. 2007, 3, 117-125. (click here for PDF) "Transition
states of the retro-ene reactions of allylic diazenes", A. Jabbari, E. J. Sorensen, K. N. Houk,
Org. Lett. 2006, 8, 3105-3107. (click
here for PDF) "Convergent,
Enantioselective Syntheses of Guanacastepenes
A and E Featuring a Selective Cyclobutane
Fragmentation", W. D. Shipe, E. J. Sorensen, J.
Am. Chem Soc. 2006, 128, 7025-7035. (click
here for PDF) "Cyclostreptin (FR182877), an Antitumor
Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site", M. C. Edler,
R. M. Buey, R. Gussio, A.
I. Marcus, C. D. Vanderwal, E. J. Sorensen, J. F.
Diaz, P. Giannakakou, E. Hamel, Biochemistry
2005, 44, 11525-11538. (click
here for PDF) "A
Diels- Alder Macrocyclization
Enables an Efficient, Asymmetric Synthesis of the Antibacterial Natural
Product Abyssomicin C", C .W. Zapf, B. A.
Harrison, C. Drahl, E. J. Sorensen, Angew. Chem. Int. Ed. 2005, 44,
6533-6537. (click
here for PDF) "Target
discovery in small-molecule cell-based screens by in situ proteome
reactivity profiling", M. J. Evans, A. Saghatelian,
E. J. Sorensen, B. F. Cravatt, Nature Biotech.
2005, 23, 1303-1307. (click here
for PDF) "Protein-Reactive
Natural Products", C. Drahl, B. F. Cravatt, E. J. Sorensen, Angew.
Chem. Int. Ed. 2005, 44, 5788-5809. (click
here for PDF) "Design,
Synthesis and Reactivity of 1-Hydrazinodienes for Use in Organic
Synthesis", G. M. Sammis, E. M. Flamme, H. Xie, D. M. Ho, E. J.
Sorensen, J. Am. Chem Soc. 2005, 127,
8612-8613. (click
here for PDF) "Palladium-Catalyzed
Ring-Forming Aminoacetoxylation of Alkenes",
E. J. Alexanian, C. B. Lee, E. J. Sorensen, J.
Am. Chem Soc. 2005, 127,
7690-7691. (click
here for PDF) "A
remarkable architectural self-construction process is discovered in a
synthesis of FR182877", C. D. Vanderwal, E. J.
Sorensen, an invited contribution to Strategies and Tactics in Organic
Synthesis, M. Harmata, Ed., Academic Press: New
York, 2004. (click
here for summary) "A
dash of proline makes things sweet", E. J.
Sorensen, G. M. Sammis, Science 2004,
305, 1725-1726. (click here
for PDF) "A
nucleophile-catalyzed cycloisomerization
permits a concise synthesis of (+)-harziphilone",
L. M. Stark, K. Pekari, E. J. Sorensen, PNAS
2004, 101, 12064-12066. (click here for PDF)
"Synthesis
of the furanosteroidal antibiotic viridin", E. A. Anderson, E. J. Alexanian,
E. J. Sorensen, Angew. Chem. Int. Ed.
2004, 43, 1998-2001. (click
here for PDF) "(–)-FR182877
is a potent and selective inhibitor of carboxylesterase-1", G. C. Adam,
C. D. Vanderwal, E. J. Sorensen, B. F. Cravatt, Angew. Chem.
Int. Ed. 2003, 42, 5480-5484. (click
here for PDF) "A
spontaneous bicyclization facilitates a synthesis
of (–)-hispidospermidin", J. Tamiya, E. J. Sorensen, Tetrahedron 2003, 59,
6921-6932. (click
here for PDF) "Architectural
self-construction in nature and chemical synthesis", E. J. Sorensen, an
invited essay for Bioorganic & Medicinal Chemistry 2003, 11,
3225-3228. (click
here for PDF) "An
enantioselective synthesis of FR182877 provides a
chemical rationalization of its structure and affords multigram
quantities of its direct precursor", C. D. Vanderwal,
D. A. Vosburg, S. Weiler,
E. J. Sorensen, J. Am. Chem Soc. 2003,
125, 5393-5407. (click
here for PDF) "Concise
stereocontrolled routes to fumagillol,
fumagillin, and TNP-470", D. A. Vosburg, S. Weiler, E. J. Sorensen,
Chirality 2003, 15, 156-166. (click
here for PDF) "Proteomic
profiling of mechanistically distinct enzyme classes using a common chemotype", G. C. Adam, E. J. Sorensen, B. F. Cravatt, Nature Biotechnology 2002, 20,
805-809. (click
here for PDF) "A
convergent synthesis of the tricyclic architecture
of the guanacastepenes featuring a selective ring
fragmentation", W. D. Shipe, E. J. Sorensen, Organic
Letters 2002, 4, 2063-2066. (click
here for PDF) "A
synthesis of (+)-FR182877, featuring tandem transannular
Diels-Alder reactions inspired by a postulated
biogenesis", D. A. Vosburg, C. D. Vanderwal, E. J. Sorensen, J. Am. Chem. Soc. 2002,
124, 4552-4553. (click
here for PDF) "Intramolecular allenolate acylations in studies toward a synthesis of
FR182877", C. D. Vanderwal, D. A. Vosburg, E. J. Sorensen, Organic Letters 2001,
3, 4307-4310. (click
here for PDF) "Profiling
the specific reactivity of the proteome with non-directed activity-based
probes", G. C. Adam, B. F. Cravatt, E. J.
Sorensen, Chemistry & Biology 2001, 8, 81-95. (click
here for PDF) "Chemical
strategies for the global analysis of protein function", B. F. Cravatt, E. J. Sorensen, an invited review for Current
Opinion in Chemical Biology 2000, 4, 663-668. (click
here for pdf) "An
enantiospecific synthesis of the potent
immunosuppressant FR901483", G. Scheffler, H. Seike, E. J. Sorensen, Angew.
Chem. 2000, 112, 4783-4785; Angew.
Chem. Int. Ed. 2000, 39, 4593-4596. (click
here for PDF) "A
concise synthesis of (–)-hispidospermidin
guided by a postulated biogenesis", J. Tamiya,
E. J. Sorensen, J. Am. Chem. Soc. 2000, 122, 9556-9557. (click
here for PDF) "Albert
Eschenmoser", E. J. Sorensen, Helv. Chim. Acta 2000, 83, 1673-1677. (click
here for PDF) "Selected,
recent developments in the chemical synthesis of biologically active natural
products", E. J. Sorensen, an invited review for Current Opinion in
Drug Discovery and Development 1999, 2, 606-630. "Postulated biogenesis of WS9885B and progress
toward an enantioselective synthesis", C. D. Vanderwal, D. A. Vosburg, S. Weiler, E. J. Sorensen, Org. Lett.
1999, 1, 645-648. (click here for PDF) You are visitor # |
