Publications

52. "Toward a synthesis of hirsutellone B by the concept of double cyclization." Reber, K. P.; Tilley, S. D.; Carson, C. A.; Sorensen, E. J. J. Org. Chem. 2013, ASAP.

51. "Taking risks in complex synthesis design." Sorensen, E. J.; Siler, D. A.; Mighion, J. D. Strategies and Tactics in Organic Synthesis. Ed. Michael Harmata, 2013. 249-273.

50. "Organic synthesis: A biochemical messenger made easily." Sorensen, E. J. Nature 2012, 489, 214-215.

49. "A chemical synthesis of 11-methoxy mitragynine pseudoindoxyl featuring the interrupted Ugi reaction." Kim, J.; Schneekloth, J. S.; Sorensen, E. J. Chem. Sci. 2012, 3, 2849-2852.

48. "Concise, stereocontrolled synthesis of the citrinadin B core architecture." Guerrero, C. A.; Sorensen, E. J. Org. Lett. 2011, 13, 5164-5167.

47. "The catalytic asymmetric Diels-Alder reactions and post-cycloaddition reductive transpositions of 1-hydrazinodienes." Xie, H.; Sammis, G. M.; Flamme, E. M.; Kraml, C. M.; Sorensen, E. J. Chem. Eur. J. 2011, 17, 11131-11134.

46. "Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis." Lotesta, S. D.; Liu, J.; Yates, E. V.; Krieger, I.; Sacchettini, J. C.; Freundlich, J. S.; Sorensen, E. J. Chem. Sci. 2011, 2, 1258-1261.

45. "A concise synthesis of the molecular framework of pleuromutilin." Liu, J.; Lotesta, S. D.; Sorensen, E. J. Chem. Commun. 2011, 47, 1500-1502.

44. "A concise and convergent synthesis of PA-824." Marsini, M. A.; Reider, P. J.; Sorensen, E. J. J. Org. Chem. 2010, 75, 7479-7482.

43. "The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis." Freundlich, J. S.; Lalgondar, M.; Wei, J. R.; Swanson, S.; Sorensen, E. J.; Rubin, E. J.; Sacchettini, J. C. Tuberculosis 2010, 90, 298-300.

42. "Synthesis enables a structural revision of the Mycobacterium tuberculosis-produced diterpene edaxadiene." Spangler, J. E.; Carson, C. A.; Sorensen, E. J. Chem. Sci. 2010, 1, 202-205.

41. "Seebach's conjunctive reagent enables double cyclizations." Chandler, B. D.; Roland, J. T.; Li, Y.; Sorensen, E. J. Org. Lett. 2010, 12, 2746-2749.

40. "A hypervalent iodine-induced double annulation enables a concise synthesis of the pentacyclic core structure of the cortistatins." Frie, J. L.; Jeffrey, C. J.; Sorensen, E. J. Org. Lett. 2009, 11, 5394-5397.

39. "Bond formations by intermolecular and intramolecular trappings of acylketenes and their applications in natural product synthesis." Reber, K. P.; Tilley, S. D.; Sorensen, E. J. Chem. Soc. Rev. 2009, 38, 3022-3034.

38. "A nature-inspired Diels-Alder reaction facilitates construction of the bicyclo[2.2.2]octane core of andibenin B." Spangler, J. E.; Sorensen, E. J. Tetrahedron 2009, 65, 6739-6745.

37. "A rapid, asymmetric synthesis of the decahydrofluorene core of the hirsutellones." Tilley, S. D.; Reber, K. P.; Sorensen, E. J. Org. Lett. 2009, 11, 701-703.

36. "An interrupted Ugi reaction enables the preparation of substituted indoxyls and aminoindoles." Schneekloth, J. S.; Kim, J.; Sorensen, E. J. Tetrahedron 2009, 65, 3096-3101.

35. "A synthesis of the tricyclic core structure of FR901483 featuring an Ugi four-component coupling and a remarkably selective elimination reaction." Seike, H.; Sorensen, E. J. Synlett 2008, 5, 695-701.

34. "Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxidates." Evans, M. J.; Morris, G. M.; Wu, J.; Olson, A. J.; Sorensen, E. J.; Cravatt, B. F. Mol. Biosyst. 2007, 3, 495-506.

33. "Classical carbonyl reactivity enables a short synthesis of the core structure of acutumine." Moreau, R. J.; Sorensen, E. J. Tetrahedron 2007, 63, 6446-6453.

32. "Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites." Buey, R. M.; Calvo, E.; Barasoain, I.; Pineda, O.; Edler, M. C.; Matesanz, R.; Cerezo, G.; Vanderwal, C. D.; Day, B. W.; Sorensen, E. J.; Lopez, J. A.; Andreu, J. M.; Hamel, E.; Diaz, J. F. Nat. Chem. Biol. 2007, 3, 117-125.

31. "Transition states of the retro-ene reactions of allylic diazenes." Jabbari, A.; Sorensen, E. J.; Houk, K. N. Org. Lett. 2006, 8, 3105-3107.

30. "Convergent, enantioselective syntheses of guanacastepenes A and E featuring cyclobutane framentation." Shipe, W. D.; Sorensen, E. J. J. Am. Chem. Soc. 2006, 128, 7025-7035.

29. "Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site." Edler, M. C.; Buey, R. M.; Gussio, R.; Marcus, A. I.; Vanderwal, C. D.; Sorensen, E. J.; Diaz, J. F.; Giannakakou, P.; Hamel, E. Biochemistry 2005, 44, 11525-11538.

28. "A Diels-Alder macrocyclization enables an efficient, asymmetric synthesis of the antibacterial natural product abyssomicin C." Zapf, C. W.; Harrison, B. A.; Drahl, C.; Sorensen, E. J. Angew. Chem. Int. Ed. 2005, 44, 6533-6537.

27. "Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling." Evans, M. J.; Saghatelian, A.; Sorensen, E. J.; Cravatt, B. F. Nature Biotech. 2005, 23, 1303-1307.

26. "Protein-reactive natural products." Drahl, C.; Cravatt, B. F.; Sorensen, E. J. Angew. Chem. Int. Ed. 2005, 44, 5788-5809.

25. "Design, synthesis and reactivity of 1-hydrazinodienes for use in organic synthesis." Sammis, G. M.; Flamme, E. M.; Xie, H.; Ho, D. M.; Sorensen, E. J. J. Am. Chem. Soc. 2005, 127, 8612-8613.

24. "Palladium-catalyzed ring-forming aminoacetoxylation of alkenes." Alexanian, E. J.; Lee, C. B.; Sorensen, E. J. J. Am. Chem. Soc. 2005, 127, 7690-7691.

23. "A remarkable architectural self-construction process is discovered in a synthesis of FR182877." Vanderwal, C. D.; Sorensen, E. J. An invited contribution to Strategies and Tactics in Organic Synthesis. M. Harmata, Ed. Academic Press: New York, 2004

22. "A dash of proline makes things sweet." Sorensen, E. J.; Sammis, G. M. Science 2004, 305, 1725-1726.

21. "A nucleophile-catalyzed cycloisomerization permits a concise synthesis of (+)-harziphilone." Stark, L. M.; Pekari, K.; Sorensen, E. J. PNAS 2004, 101, 12064-12066.

20. "Synthesis of the furanosteroidal antibiotic viridin." Anderson, E. A.; Alexanian, E. J.; Sorensen, E. J. Angew. Chem. Int. Ed. 2004, 43, 1998-2001.

19. "(-)-FR182877 is a potent and selective inhibitor of carboxylesterase-1." Vanderwal, C. D.; Sorensen, E. J.; Cravatt, B. F. Angew. Chem. Int. Ed. 2003, 42, 5480-5484.

18. "A spontaneous bicyclization facilitates a synthesis of (-)-hispidospermidin." Tamiya, J.; Sorensen, E. J. Tetrahedron 2003, 59, 6921-6932.

17. "Architectural self-construction in nature and chemical synthesis." Sorensen, E. J. An invited essay for Bioorganic & Medicinal Chemistry 2003, 11, 3225-3228.

16. "An enantioselective synthesis of FR182877 provides a chemical rationalization of its structure and affords multigram quantities of its direct precursor." Vanderwal, C. D.; Vosburg, D. A.; Weiler, S.; Sorensen, E. J. J. Am. Chem. Soc. 2003, 125, 5393-5407.

15. "Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470." Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Chirality 2003, 15, 156-166.

14. "Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes." Adam, G. C.; Sorensen, E. J.; Cravatt, B. F. Mol. & Cell. Proteomics 2002, 1, 828-835.

13. "Chemical strategies for functional proteomics." Adam, G. C.; Sorensen, E. J.; Cravatt, B. F. Mol. & Cell. Proteomics 2002, 1, 781-790.

12. "Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype." Adam, G. C.; Sorensen, E. J.; Cravatt, B. F. Nature Biotechnology 2002, 20, 805-809.

11. "A convergent synthesis of the tricyclic architecture of the guanacastepenes featuring a selective ring fragmentation." Shipe, W. D.; Sorensen, E. J. Org. Lett. 2002, 4, 2063-2066.

10. "A synthesis of (+)-FR182877, featuring tandem transannular Diels-Alder reactions inspired by a postulated biogenesis." Vosburg, D. A.; Vanderwal, C. D.; Sorensen, E. J. J. Am. Chem. Soc 2002, 124, 4552-4553.

9. "Intramolecular allenolate acylations in studies toward a synthesis of FR182877." Vanderwal, C. D.; Vosburg, D. A.; Sorensen, E. J. Org. Lett. 2001, 3, 4307-4310.

8. "Profiling the specific reactivity of the proteome with non-directed activity-based probes." Adam, G. C.; Cravatt, B. F.; Sorensen, E. J. Chemistry & Biology 2001, 8, 81-95.

7. "Chemical strategies for the global analysis of protein function." Cravatt, B. F.; Sorensen, E. J. An invited review for Current Opinion in Chemical Biology 2000, 4, 663-668.

6. "An enantiospecific synthesis of the potent immunosuppressant FR901483." Scheffler, G.; Seike, H.; Sorensen, E. J. Angew. Chem. Int. Ed. 2000, 39, 4593-4596.

5. "A concise synthesis of (-)-hispidospermidin guided by a postulated biogenesis." Tamiya, J.; Sorensen, E. J. J. Am. Chem. Soc. 2000, 122, 9556-9557.

4. "Albert Eschenmoser." Sorensen, E. J. Helv. Chim. Acta 2000, 83, 1673-1677.

3. "Selected, recent developments in the chemical synthesis of biologically active natural products." Sorensen, E. J. An invited review forCurrent Opinion in Drug Discovery and Development 1999, 2, 606-630.

2. "Postulated biogenesis of WS9885B and progress toward an enantioselective synthesis." Vanderwal, C. D.; Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Org. Lett. 1999, 1, 645-648.

1. "A concise synthesis of fumagillol." Vosburg, D. A.; Weiler, S.; Sorensen, E. J. Angew. Chem. Int. Ed. 1999, 38, 971-974.