MANGANESE PORPHYRIN-ANTIOXIDANT REDOX COUPLES

RAPID DECOMPOSITION OF PEROXYNITRITE BY MANGANESE PORPHYRIN-ANTIOXIDANT REDOX COUPLES

Jinbo Lee , Julianne A. Hunt and John T. Groves

Bioorg. Med. Chem. Lett. 1997, in press.

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO-) to generate an oxoMn(IV) species, but Mn(III)TMPyP is not catalytic for ONOO- decomposition due to the slow reduction of oxoMn(IV) back to the Mn(III) oxidation state. However, when redox-coupled with biological antioxidants that efficiently reduce oxoMn(IV), Mn(III)TMPyP is transformed into an efficient "peroxynitrite reductase."

Editted by Jinbo Lee

Last updated on Oct. 10, 1997.