Lin S. Chen

I am currently a postdoc research associate in Princeton University, working with Dr. John Storey.

Lin S. Chen

     My research interests focus on the analysis of high-
     dimensional quantitative genomics. Specifically, I have
   worked on

Identification of causal quantitative trait transcripts
Causal inference and modeling in transcriptional regulatory networks
Dissection of variation in high-dimensional data
Clinical genomics study on trauma patients
Significance measures in multiple hypothesis testing, with an

emphasis on linkage analysis and genomics data

       Overall, I am interested in developing quantitative methods
and tools for genomics research, with the goal of contributing
to the understanding of genetics basis of human disease and
molecular biology.

     If you have any questions or suggestions, please email me at
   lschen at princeton dot edu.

Education and Background

Postdoctoral Research Associate 02/2008 - 08/2008 (expected)

Lewis-Sigler Instituate for Integrative Genomics, Princeton University
Advisor: John Storey

Ph.D., Biostatistics 09/2003 - 01/2008

Department of Biostatistics, University of Washington
Advisor: John Storey

Thesis Title: Causal Modeling in Quantitative Genomics [abstract]

B. S., Economics 09/1998 - 06/2002

School of Economics, Peking University, Beijing, China

Publications

Chen L and Storey JD. (2006) Relaxed significance criteria for linkage analysis. Genetics, 173: 2371-2381. [ website ]

Dembo G, Chen L, Vater Y, Breslow N and Martay K. (2006) Double blind randomized controlled trial on the effects of mannitol on the postreperfusion syndrome during orthotopic liver transplantations. International Journal of Anaesthesia, 6: 1-13. [ website ]

Chen LS, Emmert-Streib F, and Storey JD. (2007) Harnessing naturally randomized transcription to infer regulatory relationships among genes, Genome Biology, 8: R219. [ website ]

Chen LS and Storey JD. (2007) Eigen-R2 for dissecting the variation of high-dimensional phenotypes, in preparation. [ software ]

Emmert-Streib F, Chen LS, and Storey JD. (2007) Functional annotation of genes in S. cerevisiae based on the joint betweenness measure, in preparation.

Nathens AB, Xiao W, Moldawer LL, Cobb JP, Mindrinos MN, Minei J, Moore EE, Harbrecht B, Johnson JL, Elson CM, Chen L, Storey JD, Hayden DL, Baker HV, Miller-Graziano C, Altstein LL, Hennessy L, Davis RW, Tompkins RG, and Maier RV. (2007) Determinants of early gene expression following severe traumatic injury: The impact of allogeneic blood transfusion, submitted.

Chen LS and Storey JD. (2007) Identification of casual quantitative trait transcripts from randomized genetic variation, in preparation.

Software Development

Chen LS and Storey JD. (2007) eigenR2, an R software package for dissecting variation in high-dimensional data.
Chen LS and Storey JD. (2007) TRIGGER, an R software package for inferring transcriptional regulatory network from randomized trancription data. (check out later)

Teaching

BIOST 514 Biostatistics I 2007 Fall
ECON 200 Introduction to Microeconomics 2003 Winter, 2003 Spring