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Monthly Dinner Meeting
Wednesday, March 23, 2011
our guest speaker will be
Joshua Rabinowitz, MD, PhD
Chemistry and Integrative
Genomics, Princeton University
“Towards a Comprehensive
Understanding of
Cellular Metabolism”
Social mixer begins at
5:30 pm in the Friend Center Atrium, Princeton University.
Presentation is at 6:15 pm in the Auditorium followed by dinner
at Kalluri Corner Restaurant, Nassau St.
Abstract
The metabolic network is uniquely well
mapped. However, the means by which the hundreds of reactions
involved in metabolism are regulated in order to meet cellular
needs remains incompletely understood. This talk will present
mass spectrometry-based techniques for quantitative metabolomics
and their application to systems-level metabolic analysis.
Metabolomic data from E. coli will be used to reveal regulatory
connections linking glycolysis to the citric acid cycle, and the
citric acid cycle to nitrogen assimilation. A second case
study, focusing on human cytomegalovirus infection, will
highlight the potential for translating metabolomic discoveries
into new therapeutic approaches.
Biography
Dr. Rabinowitz received B.A. degrees in
Mathematics and in Chemistry from the University of North
Carolina at Chapel Hill in 1994. He went on to Stanford
University where he received his Ph.D. in Biophysics in 1999
and M.D in 2001. He was co-founder and vice president of
research of Alexza Pharmaceuticals from 2000–2004. The
company’s area of focus was accelerating the onset of drug
action through thermally generated aerosols. He joined
Princeton University, Department of Chemistry & Lewis-Sigler
Institute for Integrative Genomics in 2004 where he is
currently an Associate Professor.
His research laboratory aims to achieve
a quantitative, comprehensive understanding of cellular
metabolism. His lab has developed methods for measuring a
wide range of cellular metabolites using state-of-the-art
mass spectrometry technology. They have innovated
approaches integrating informatics to quantitate metabolic
fluxes by interpret isotope-labeling data within a rigorous
chemical-kinetic framework.
Dr. Rabinowitz is the inventor on
nearly 100 patents and author of nearly 100 publications.
He is the recipient of numerous awards including the Kavli
Frontiers of Science Scholar, Kavli Foundation and National
Academy of Sciences, 2008, CAREER Award, National Science
Foundation, 2007 and Beckman Young Investigator Award,
Arnold and Mabel Beckman Foundation, 2005.
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