Polymeric Nanoparticles: Formulation and Stability
Polymeric nanoparticles are formed by using a classical precipitation technique, Flash nanoprecipitation. The physical stability of drug and nanoparticle, and the aggregation state of drug in nanoparticle cores have been correlated with the physical variables using model drug molecules: itraconazole and odanacatib and fluorescent dyes: pyrene, hostasol yellow and Amphotericin B.
Polymeric Nanoparticles: Therapeutics Delivery
Application of nanoparticles has been extended by encapsulating Nitric Oxide (NO) prodrugs, anti-cancer drug molecules, into various polymeric nanoparticles. Impact/advantages of nanoparticle formulation are observed with respect to the PEG protection, in vivo circulation time, efficacy and in vivo tumor suppression.
Lipid Nanoparticles: siRNA Delivery Vehicles
Lipid nanoparticles have been used as suitable vehicles for siRNA delivery. The formation of the lipid nanoparticle, structure evolution and efficacy are analyzed by tuning various variables involved during the self-assembly process of siRNA and cationic lipids. The goal is to reduce the particle size ~50-70 nm and to achieve high RNA encapsulation.
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