MOLECULar reactivity IN COMPLEX SYSTEMS

New techniques are being developed to follow the reactivity of a molecular-scale probe in real time and to directly correlate the chemical or physical processes with the 3D spatial location of the probe.

Instrumentation and Technology Development

Real-Time 3D Single-Particle Tracking Spectroscopy is a new techniqe that allows us to follow individual nanoparticles in real time as they move in three dimensions and at the same time acquire time-dependent spectroscopic information. Since our initial conceptualization and demonstration in 2006, we continue to advance this technique and at the same time expanding the scope of application.

Local Temperature in Living Cells

It has long been believed that intra-cellular temperature response is uniform. Our recent experiment, however, shows that the local temperature progression inside living cells is heterogeneous (ACS Nano 2011). This experiment has enabled us to ask many interesting new questions; some are currently being pursued in our lab.

Additional projects coming soon!