- Ecology and Evolutionary Biology
I am an evolutionary ecologist with strong interests in the processes that drive heterogeneity in hosts, parasites, and diseases. I'm particularly keen to understand the role of immune systems in brokering host-parasite interactions, generating substantial self-harm (or immunopathology), and altering transmission dynamics of parasites. Recent projects in the Graham Group have focused on the following questions:
- Why do sheep vary so much in antibody responsiveness?
- What are the consequences of immunopathology for transmission of malaria parasites?
- Which cytokines primarily drive a cytokine storm?
- What are the relative roles of resource limitation and immunological killing in within-host control of parasite populations?
- Why do adaptive immune responses cross-react?