Bio-MOSFET: The Next Frontier for CMOS Technology
Speaker: Edwin Kan, Cornell University
Department: Electrical Engineering
Location: Engineering Quadrangle J201
Date/Time: Thursday, April 4, 2013, 7:30 p.m. - 9:00 p.m.
With mass production fast marching to 17nm CMOS technology and beyond, we are fast approaching the information resolution of the biological systems such as DNA/RNA and cellular ion channels. The close proximity of CMOS sensing, amplification, data conversion and transmission enables cost reduction and least noise injection. On the one hand, many exciting applications can be realized based on never-before accessible biological and biomedical information, but on the other hand, many aspects of fundamental understanding on solid-fluid interface with bio-molecules and cells are still lacking. Conventional ion-sensitive FET (ISFET) faces severe challenges in reliable operations and invasiveness reduction.
This talk will present the device operations of the chemoreceptive MOS (C?MOS) sensor for monitoring ions, biomarker proteins, pathogen DNA/mRNA, cellular action potentials and exocytosis. Modeling of the surface layers with steric and molecular correlation effects will be investigated in detail to illustrate different modes of sensing and actuation. As illustration of reliable data collection, we will present two successful enzyme-free and readout-label-free applications of fast epidemic disease diagnosis and intercellular signaling monitoring of mast and chromaffin cells. With the unparalleled resolution in space and time, high sensitivity and versatile integration, this CMOS biosensor platform is potential to bring forth the next-generation molecular interface to the electronic computer.
Y. N. Shen, Z. Liu, C. Lee, B. A. Minch and E. C. Kan, Charge-based chemical sensors: a neuromorphic approach by the chemoreceptive neuron MOS transistors (C?MOS), IEEE Trans. Electron Devices, vol. 50, no. 10, pp. 2171-2178, Oct. 2003.
K. Jayant, M. R. Hartman, J. B. Phelps, P. H. Gordon, D. Luo, L. Pollack and E. C. Kan, Electrolytic charge inversion at programmable CMOS sensor interface, 16th Intl. Conf. Solid-State Sensors, Actuators and Microsystems (Transducer 11), Beijing, China, June 5 9, 2011.
X. Duan, R. Gao, P. Xie, T. Cohen-Karni, Q. Qing, H.S. Choe, B. Tian, X. Jiang and C.M. Lieber, Intracellular recordings of action potentials by an extracellular nanoscale field-effect transistor, Nature Nanotechnol., vol. 7, pp. 174-179, 2012.