Inorganic Materials for Long Term Controlled Release of Growth Factors and other Biological Molecules
Speaker: Paul Ducheyne, University of Pennsylvania
Department: Electrical Engineering
Location: Engineering Quadrangle J201
Date/Time: Wednesday, April 17, 2013, 7:30 p.m. - 9:00 p.m.
Finding solutions to deliver drugs and large biological molecules in a controlled fashion is not a contemporary issue; however, it remains an important biomaterials and pharmacological goal. In this seminar, we focus on inorganic materials, such as sol-gel processed silica and mesoporous silica. In a first part, the structure-property-processing relationships of oxides and other inorganic materials as controlled release systems are highlighted and the benefits of ceramic controlled release materials described. Furthermore, hybrid oxide polymeric controlled release materials will be discussed, both in macroscopic form as well as in materials with critical nano properties. It is the intent to discuss the general sol-gel process, the biocompatibility of the sol gel oxides, the release kinetics of the incorporated molecules, and the various unique therapies that are winding their way to clinical use.