Trying to unravel the roles that a small set of genes play in the regulation of a human trait is a daunting enough task, but when scientists try to apply the same analytic methods to a specific tissue or organ, they quickly run into a storm of information.
The functional role of any one gene is quickly obscured by a cascade of genes whose influence combines with that of other genes and environmental factors to affect multiple pathways. What starts as a few bits of information quickly becomes
Two members of the engineering faculty, Celeste Nelson and Clifford Brangwynne, have been named to the inaugural group of Faculty Scholars, a joint award from the Howard Hughes Medical Institute, the Simons Foundation and the Bill & Melinda Gates Foundation.
Princeton engineers have found that, in breast cancer, tumor hardness and lack of oxygen trigger a biological switch that causes certain cells to embark on a cancer-promoting program.
Investigators eager to uncover the genetic basis of autism could now have hundreds of promising new leads thanks to a study by Princeton University and Simons Foundation researchers.
Researchers from Princeton University are joining with colleagues from U.S. government laboratories in an effort to dramatically improve the test for the Ebola virus. The goal is to offer a quick, accurate and inexpensive method to help contain future epidemics.
A study by biological engineers at Princeton solves a longtime paradox about how a key constituent of cells self-organizes intself into working structure despite being made of liquid. These insights into the form and function of the nucleolus could ultimately point toward new ways to treat disease.
Researchers at the intersection of engineering and biology are setting the groundwork for advances in health and medicine, including curing diseases such as Alzheimer's, growing replacement organs and preventing developmental abnormalities.
When graduate student Yogesh Goyal told an audience at Princeton University in October how his research could help doctors diagnose patients with difficult-to-characterize congenital disorders, he was describing more than a potential medical breakthrough.
Princeton researchers have observed the artistry of developing lungs unfold in a petri dish and have arrived at a surprising conclusion about the forces that shape it.
Faculty members from several departments with expertise in biology and engineering will hold a day of lectures and discussions to celebrate bioengineering at Princeton on October 2, 2015.
Research presented at the Innovation Forum ranged from sustainable furniture production to groundwater bioremediation. A member of each team delivered a three-minute pitch to a panel of judges consisting of investors and business leaders, who then awarded prize money to their top choices.
"We thought: does the nucleolus' assembly and function depend on the size of the cell?" said Clifford Brangwynne, the lead researcher and an assistant professor of chemical and biological engineering at Princeton. "If this were true, then it could provide a feedback mechanism for regulating cell growth."
The National Institutes of Health has awarded a $2.43 million grant to Princeton engineer Michael McAlpine, to investigate new ways to interweave electronic and biological materials to ultimately produce bionic organs for a range of scientific and biomedical applications.
Princeton researchers have demonstrated that bubbles bursting at the surface of a liquid don't just spray particles upward but also push some down into the liquid -- a finding with potentially broad industrial uses.
Princeton University researchers have developed a way to use a laser to measure people's blood sugar, and, with more work to shrink the laser system to a portable size, the technique could allow diabetics to check their condition without pricking themselves to draw blood.