Development of Micro/nanofluidic Electrokinetic Bioanalytical Systems
Speaker: Sumita Pennathur, Mechanical Engineering, UC Santa Barbara
Series: MAE Departmental Seminars
Location: Bowen Hall Room 222
Date/Time: Friday, October 10, 2014, 3:30 p.m. - 4:30 p.m.
Micro and nanofluidic technologies provide revolutionary opportunities to separate, identify and analyze biomolecular species. The coupled physics unique to nanofluidic systems allow for separations based on different analyte properties, including charge, size, conformation, hydrophobicity, and mass. Coupled with optical or electronic detection technologies, such systems allow for great opportunities the field of biomolecular analysis, providing separation, identification, and detection of biomolecules with superior speed, sensitivity, selectivity and quantitation. In this talk, the results of investigations preformed in our lab aimed at understanding the role and impact of the interactions between biomolecules and our fused silica nanofluidic channels will be discussed. Specifically, we will show (1) recent theoretical as well as experimental investigations showing the unique separation capabilities of nanofluidic channels, (2) our ability to predict biomolecular size, shape and conformation from comparison between modeling and experimental data, and (3) the prediction of DNA and protein kinetic interactions in such systems. The results of these investigations will help provide guidance to the design and fabrication of truly translational studies in biology and medicine.
Dr. Pennathur received her B.S. and M.S. in Aerospace and Aeronautical Engineering from M.I.T. (2000 and 2001 respectively), and Ph.D. in Mechanical Engineering from Stanford University (2006). Prior to joining UCSB in 2007, she performed postdoctoral studies at both Sandia National Laboratories and University of Twente. Since arriving at UCSB, Pennathur has contributed significantly to the fields of nanofluidics and interfacial science. She has been able to push the envelope in both theoretical and experimental characterization of nanofluidic channels. Furthermore, she has discovered novel nanoscale concentration mechanisms which focus analytes of interest within nanofluidic channels and has demonstrated unique quantitative separations of various biomolecules. Finally, she has developed a novel fabrication process for on-chip detection of biomolecules, which has the potential to revolutionize bio-analytical devices, eliminating the need for laborious optical tagging of samples. These major contributions have been disseminated in the form of over 60 archived journal publications, books or conference papers, 3 patent applications, and over 50 invited presentations. Notable awards include the DARPA young faculty award (2008), the UC Regents Junior Faculty Fellowship (2009), the PECASE (presidential early career award in science and engineering) award (2010), and the Santa Barbara Chamber of Commerce Innovator of the Quarter Award (2012).