News at Princeton

Tuesday, April 25, 2017

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Inner workings of the brain I

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Using two-photon microscopy in the laboratory of virologist Lynn Enquist, Stephan Thiberge, manager of the imaging facility in the Lewis-Sigler Institute for Integrative Genomics, and graduate student Andrea Gransted visualized pseudorabies virus particles moving in neurons growing in a tissue culture dish. The protein shells, or capsids, which surround the viral DNA can be seen because they carry a fluorescent protein that glows when illuminated by the laser in the microscope. These glowing capsids move rapidly in the axons suggesting how they can be used to follow the wiring patterns in the brain. Read more.

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