Dehydroepiandrosterone

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5-Dehydroepiandrosterone (5-DHEA) is a 19-carbon endogenous[1] natural steroid hormone. It is the major secretory steroidal product of the adrenal glands[2] and is also produced by the gonads and the brain.[3] DHEA is the most abundant circulating steroid in humans. [4]

DHEA has been implicated in a broad range of biological effects in humans and other mammals. It acts on the androgen receptor both directly and through its metabolites, which include androstenediol and androstenedione, which can undergo further conversion to produce the androgen testosterone and the estrogens estrone and estradiol.[5] DHEA is also a potent sigma-1 agonist.[6] It is considered a neurosteroid.[5]

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