Uric acid

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decomposes on heating

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Uric acid (or urate) is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. Uric acid is created when the body breaks down purine nucleotides.

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Chemistry

Uric acid is a diprotic acid with pKa1=5.4 and pKa2=10.3.[2] Thus in strong alkali at high pH it forms the dually charged full urate ion, but at biological pH or in the presence of carbonic acid or carbonate ions it forms the singly charged hydrogen or acid urate ion as its pKa2 is greater than the pKa1 of carbonic acid. As its second ionization is so weak the full urate salts tend to hydrolyse back to hydrogen urate salts and free base at pH values around neutral. It is aromatic because of the purine functional group.

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