Monthly Dinner Meeting
Tuesday, April 3, 2012
our guest speaker will be
Abigail Doyle, PhD
Princeton University,
Department of Chemistry
“The
Development of Catalytic Methods
for
Nucleophilic Fluorination.”
Location:
Frick Laboratory, Princeton University
Social mixer: 5:30 pm in
CaFe area, Taylor Commons
Presentation: 6:30 pm in
the Auditorium
Dinner:
following presentation, in CaFe,
Abstract
An
expansive array of medicines, agrochemicals, and materials
contain fluorine due to the unique chemical properties that
the element confers on organic molecules. One of the chief
obstacles to the discovery and production of these compounds
is the availability of synthetic methods for carbon–fluorine
(C–F) bond formation. The most abundant and inexpensive
fluorine sources, nucleophilic fluoride salts, typically
suffer from low solubility, high hygroscopicity, and strong
Brønsted basicity, rendering them recalcitrant reagents for
chemical synthesis. My laboratory has recently identified
two strategies that achieve mild and efficient nucleophilic
fluorination using transition metal catalysis. This lecture
will describe the development and scope of these
stereoselective methods, which represent exciting platforms
for the invention of a wide spectrum of chemical
transformations. Insight gained from mechanistic studies
will also be presented.
Biography
Abigail Doyle was born in Princeton, NJ in 1980. She
received her A.B. and A.M. summa cum laude in Chemistry and
Chemical Biology from Harvard University in 2002. As an
undergraduate, she investigated iron-catalyzed epoxidations
of alkenes in collaboration with Dr. Christina White. She
began her graduate studies at Stanford University working
with Professor Justin Du Bois on the development of gold
catalysts for the hydration of unactivated alkenes. In 2003,
Abby moved to Harvard University and joined the laboratory
of Professor Eric Jacobsen. Her graduate research included
the discovery of a transition metal-catalyzed
enantioselective alkylation of tributyltin enolates with
alkyl halides and the development of a thiourea catalyst for
enantioselective nucleophilic additions to prochiral
oxocarbenium ions. Abby began as an Assistant Professor in
the Department of Chemistry at Princeton University in July
2008. She is the recipient of the 2011 New Investigator
Award in Organic Chemistry from Boehringer-Ingelheim, and
was recently named an Alfred P. Sloan Foundation Fellow.
Abby and her group have made significant contribution in the
area of asymmetric nucleophilic C-F bond formation, and
nickel catalyzed cross-coupling reactions..
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