Princeton Section

 

Princeton ACS Meeting Announcement

 

Monthly Dinner Meeting

 

Tuesday, April 3, 2012

our guest speaker will be

 

Abigail Doyle, PhD

Princeton University, Department of Chemistry

 

“The Development of Catalytic Methods

for Nucleophilic Fluorination.”

 

Location:         Frick Laboratory, Princeton University

Social mixer:   5:30 pm in CaFe area, Taylor Commons

Presentation:   6:30 pm in the Auditorium

Dinner:            following presentation, in CaFe,

 

Abstract

An expansive array of medicines, agrochemicals, and materials contain fluorine due to the unique chemical properties that the element confers on organic molecules. One of the chief obstacles to the discovery and production of these compounds is the availability of synthetic methods for carbon–fluorine (C–F) bond formation. The most abundant and inexpensive fluorine sources, nucleophilic fluoride salts, typically suffer from low solubility, high hygroscopicity, and strong Brønsted basicity, rendering them recalcitrant reagents for chemical synthesis. My laboratory has recently identified two strategies that achieve mild and efficient nucleophilic fluorination using transition metal catalysis. This lecture will describe the development and scope of these stereoselective methods, which represent exciting platforms for the invention of a wide spectrum of chemical transformations. Insight gained from mechanistic studies will also be presented.

 

Biography

Abigail Doyle was born in Princeton, NJ in 1980. She received her A.B. and A.M. summa cum laude in Chemistry and Chemical Biology from Harvard University in 2002. As an undergraduate, she investigated iron-catalyzed epoxidations of alkenes in collaboration with Dr. Christina White. She began her graduate studies at Stanford University working with Professor Justin Du Bois on the development of gold catalysts for the hydration of unactivated alkenes. In 2003, Abby moved to Harvard University and joined the laboratory of Professor Eric Jacobsen. Her graduate research included the discovery of a transition metal-catalyzed enantioselective alkylation of tributyltin enolates with alkyl halides and the development of a thiourea catalyst for enantioselective nucleophilic additions to prochiral oxocarbenium ions. Abby began as an Assistant Professor in the Department of Chemistry at Princeton University in July 2008.  She is the recipient of the 2011 New Investigator Award in Organic Chemistry from Boehringer-Ingelheim, and was recently named an Alfred P. Sloan Foundation Fellow.  Abby and her group have made significant contribution in the area of asymmetric nucleophilic C-F bond formation, and nickel catalyzed cross-coupling reactions..

 

Reservations:

The meeting will be held in Frick Laboratory, Princeton University. The social mixer will begin at 5:30 pm in the CaFe area of Taylor Commons.  The lecture will be held in the Auditorium at 6:30 pm followed by dinner in Taylor Commons (CaFe area).  Frick Laboratory is located at the east end of the pedestrian bridge on Washington Rd, adjacent to the Weaver Track and Field Stadium.  Parking is available in Lot 21, corner of Faculty Road and Fitzrandolph Road or other lots along Ivy Lane (other parking options).  The seminar is free and open to the public.  Reservations are required for dinner, which is $20 ($10 for students).  Please contact Louise Lawter (215-428-1475) by March 27 to make reservations. Reservations must be canceled no later than March 27 to avoid being billed for the dinner.