Yibin Kang

 

Personal Data

                                                                                               

Address:                Department of Molecular Biology     

      Princeton University

      LTL 255, Washington Road

      Princeton, NJ 08544                                      

Phone:                   (609) 258-8834

Fax:                       (609) 258-2340

E-mail:                   ykang@molbio.princeton.edu

URL:                     http://www.molbio1.princeton.edu/kang/

                                                                  

Education

 

• 1991-1995          B.S. (Genetics)            Fudan University, Shanghai, China

• 1996-2000          Ph.D. (Genetics)         Duke University, Durham, NC

 

Honors and Awards

 

• 1990                    First prize, National High School Chemistry Competition, China

• 1991-1995          Fudan University People’s Scholarship

• 1993                    Fudan University Mao Cheng-Si Scholarship

• 1994                    Fudan University Xu Zeng-Shou Scholarship

• 1995                    Fudan University Outstanding Graduate Award

• 2001-2004          Irvington Institute Postdoctoral Fellowship for Immunological Research

• 2004                    AIMM-ASBMR John Haddad Young Investigator Award

• 2004                    Memorial Sloan-Kettering Cancer Center Annual Postdoctoral Research Award

• 2005                    The Padget Foundation Young Investigator Award

• 2005                    American Cancer Society Research Scholar Award

• 2006                    Department of Defense Breast Cancer Research Program Era of Hope Scholar Award

 

Professional Experience

 

• 1993-1995                      Undergraduate Research Assistant at Dr. Jianhua Chai’s Laboratory

Department of Genetics, Fudan University, Shanghai, China

 

Physical and expression mapping of the subcentromeric regions (Xp11.2 and Xp21.1-21.3) in the short arm of the human X chromosome.

 

• 1996-2000          Graduate Research Assistant at Dr. Bryan R. Cullen’s Laboratory

                              Department of Genetics and Howard Hughes Medical Institute

                              Duke University Medical Center, Durham, NC

 

Transcriptional and post-transcriptional regulation of eukaryotic gene expression, using retroviruses as a model system.

 

• 2000-2004          Postdoctoral Research Associate at Dr. Joan Massagué’s Laboratory

                              Cell Biology Program and Howard Hughes Medical Institute

                              Memorial Sloan-Kettering Cancer Center, New York

 

TGFb cytostasis program and the role of TGFb in tumorigenesis and metastasis of human cancer.

Molecular basis of breast cancer bone metastasis.

 

• 2004-present       Assistant Professor

                              Department of Molecular Biology, Princeton University, Princeton, NJ

                              Associate Member, Cancer Institute of New Jersey, New Brunswick, NJ

 

Using functional genomics and systems biology approaches to study molecular mechanisms of cancer metastasis.  Signaling pathways involved in tumor-stroma interactions during metastasis.

 

Professional Membership

 

•  American Association for Cancer Research (AACR)

•  American Association for Advancement of Science (AAAS)

•  American Society of Biochemistry & Molecular Biology (ASBMB)

•  Chinese Biological Investigator Society (CBIS)

•  Metastasis Research Society (MRS)

 

Invited Lectures

 

·         AIMM-ASBMR John Haddad Young Investigators Meeting, Snowmass, Colorado (3/30/2004)

·         Hermelin Brain Tumor Center Symposium on Metastatic Disease, Henry Ford Hospital, Detroit, Michigan (5/7/2004)

  • 34th International Sun Valley Workshop on Skeletal Tissue Biology, Sun Valley, Idaho (8/1/2004)
  • 10th International Congress of Metastasis Research Society, Genoa, Italy (9/17/2004)
  • Fred Hutchinson Cancer Center, Seattle, Washington (11/23/2004)
  • Biomolecular Technologies: Discovery to Hypothesis, Savannah, Georgia (02/06/2005)
  • Alfred I. Dupont Hospital, Wilmington, Delaware (03/21/2005)
  • Skeletal Complications of Malignancy IV, Bethesda, Maryland (04/30/2005)
  • EuroCancer 2005, Paris, France (06/22/2005)
  • The Cancer Institute of New Jersey, New Brunswick, New Jersey (10/18/2005)
  • AACR Special Conference: Cancer, Protease and Tumor Microenvironmen, Bonita Springs, Florida (12/2/2005)
  • Society of Chinese Biological Investigators Annual Meeting, Boulder, Colorado (12/19/2005)
  • Annual Retreat on Cancer Research in New Jersey, Piscataway, New Jersey (5/25/2006)
  • BRECOSM Breast Cancer and Metastasis Meeting, Paris, France (6/22/2006)
  • 11th International Congress of Metastasis Research Society, Tokushima, Japan (9/3/2006)
  • National Cancer Center, Tokyo, Japan (9/7/2006)
  • University of Massachusetts Medical Center, Worcester, Massachusetts (10/25/2006)
  • Duke University, Durham, North Carolina (11/09/2006)
  • VI International Meeting on Cancer Induced Bone Disease, San Antonio, Texas (12/10/2006)
  • Rutgers University, (2/5/2006)
  • The 2nd New York Academy of Sciences Conferences on Skeletal Biology and Medicine (4/27/2007)
  • Gordon Research Conference, Biddeford, Maine (7/15/2007)
  • Skeletal Complications of Malignancy V, Philadelphia, Pennsylvania (10/25/2007)

 

Peer-reviewed Publications

 

1. Kang Y, Blair WS, and Cullen BR. (1998) Identification and functional characterization of a high affinity Bel-1 DNA binding site located in the human foamy virus internal promoter.  J. Virol., 72:504-11.

 

2. Kang Y, and Cullen BR. (1998) Derivation and functional characterization of the consensus DNA binding sequence for the Tas transcriptional activator of simian foamy virus type 1. J. Virol., 72:5502-9.

 

3. Kang Y, and Cullen BR. (1999) The human Tap protein is a nuclear mRNA export factor that contains novel RNA binding and nucleocytoplasmic transport sequences. Genes & Dev., 13:1126-39.

 

     Editorial by:        Strambio-de-Castillia C, and Rout MP. (1999) Nature Cell Biol., 1: E31-2.

 

4. Kang Y, Bogerd H, Yang J, and Cullen BR. (1999) Analysis of the RNA binding specificity of the human Tap nuclear RNA export factor. Virology, 262:200-9.

 

5. Truant R*, Kang Y*, and Cullen BR. (1999) The human Tap nuclear RNA export factor contains a novel transportin dependent NLS that lacks NES function. J. Biol. Chem., 274:32167-71.

 

* The first two authors contributed equally to this work.

 

6. Kang Y, Bogerd H, and Cullen BR. (2000) Analysis of cellular factors that mediate nuclear export of RNAs bearing the Mason-pfizer monkey virus constitutive transport element. J. Virol., 74:5863-71.

 

7. Neufeld KL, Nix DA, Bogerd H, Kang Y, Beckerle MC, Cullen BR, and White RL. (2000) Nuclear export of Adenmatous Polyposis Coli protein regulate b-Catenin levels in the nucleus. Proc. Natl. Acad. Sci., 97:12085-90.

 

8. Chen C*, Kang Y*, and Massagué J. (2001) Defective repression of c-myc in breast cancer cells: A loss at the core of the TGF-b growth arrest program. Proc. Natl. Acad. Sci., 98:992-9.

 

* The first two authors contributed equally to this work.

 

9. Coburn GA, Wiegand HL, Kang Y, Ho DN, Georgiadis MM, and Cullen BR. (2001) Using viral species specificity to define a protein: RNA interaction surface. Genes & Dev., 15:1194-205.

 

10. Wiegand HL, Coburn GA, Zeng Y, Kang Y, Bogerd HP, and Cullen BR. (2002) Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complex. Mol. Cell Biol., 22:245-56.

 

11. Ho DN, Coburn GA, Kang Y, Cullen BR, and Georgiadis MM. (2002) The crystal structure and mutational analysis of a novel RNA-binding domain found in the human Tap nuclear mRNA export factor. Proc. Natl. Acad. Sci., 99:1888-93.

 

12. Chen C, Kang Y, Siegel PM, and Massagué J. (2002) E2F4/5 and p107 as Smad cofactors linking the TGFb receptor to c-myc repression. Cell, 110:19-32.

 

     Editorial by:           Kowalik TF. (2002) Mol. Cell, 10:7-8.

 

13. Xu L, Kang Y, Col S, and Massagué J. (2002) Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFb signaling complexes in the cytoplasm and nucleus. Mol. Cell, 10:271-82.

 

     Editorial by:           Heinrichs A. (2002) Nature Reviews Mol. Cell Biol., 3:728.

 

14. Kang Y, Chen C, and Massagué J. (2003) A self-enabling TGFb response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell, 11:915-26.

 

15. Kang Y, Siegel PM, Shu WP, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA, and Massagué J. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell, 3:537-49. (Cover Article)

 

     Editorial by:           Hynes RO. (2003) Cell, 113:821-23.

                                    Pilcher HR. (2003) Nature, 424:143.

                                    van’t Veer LJ, and Weigelt B. (2003) Nature Medicine, 9:999-1000.

                                    Greenwood E. (2003) Nature Reviews Cancer, 3:549.

                                    Welch DR. (2004) Breast Cancer Research, 6:61-4.

 

16. Bodem J, Kang Y and Flügel RM. (2004) Comparative functional characterization of the feline foamy virus transactivator reveals its species specificity. Virology, 318:32-6.

 

17. Kang Y and Massagué J. (2004) Epithelial-mesenchymal transition: twist in development and metastasis. Cell, 118:277-9.

 

18. Minn AJ, Kang Y, Gupta G, Panomarev V, Serganova I, Blasberg R, and Massagué J. (2005) Distinct organ-specific metastasis potential of individual breast cancer cells carrying a uniform poor-prognosis gene expression signature. J. Clin. Invest., 115:44-55.

 

Editorial by:            Hutchinson E. (2005) Nature Reviews Cancer, 5:88.

 

19. Kang Y (2005) Functional genomics analysis of cancer metastasis: biologic insights and clinical implications. Expert Rev. Mol. Diagn., 5: 385-95.

 

20. Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen C, Manova-Todorava K, Blasberg R, Gerald WL, and Massagué J. (2005) Breast cancer bone metastasis mediated by Smad tumor suppressor pathway. Proc. Natl. Acad. Sci., 102: 13909-14.

 

21. Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordon-Cardo C, Olshen AB, Gerald WL, and Massagué J. (2005) Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol. 70: 1-10.

 

22. Kang Y. (2006) Pro-metastatic function of TGFb mediated by the Smad pathway. J. Cell.  Biochem., 98: 1380-90.

 

23. Kang Y. (2006) New tricks against an old foe: dissecting tissue tropism in breast cancer metastasis. Breast Disease, in press.

 

24. Li F, Tiede B, Massagué J and Kang Y. (2006) Beyond tumorigenesis: the role of cancer stem cells in metastasis. Submitted.