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Martin F. Semmelhack
361 Frick Laboratory
Princeton, NJ 08544
Lab #: 303
Office: 609-258-5501
Lab #1: 609-258-6164
Lab #2: 609-258-6165
Email
mfshack@princeton.edu

Updated 3/12/07
Chrissy Carroll

Quorum Sensing Research Abstract: The unstable bacterial metabolic product, DPD, and the related natural product, laurencione, are shown to have a high affinity for borate complexation, through the hydrated analog. The boron complex of DPD is AI-2, the interspecies quorum sensing signal in bacteria, and an affinity column with a borate resin is effective in providing the first method for concentrating and purifying AI-2 from the biosynthetic product.

From: Semmelhack, M. F.; Campagna, S. r.; Hwa, C.; Federle, M. J.; Bassler, B. L. Org. Lett., 2004, 6, 2635-2637. “Boron Binding with the Quorum Sensing Signal AI-2 and Analogues.”

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