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Martin F. Semmelhack
361 Frick Laboratory
Princeton, NJ 08544
Lab #: 303
Office: 609-258-5501
Lab #1: 609-258-6164
Lab #2: 609-258-6165
Email
mfshack@princeton.edu

Updated 3/12/07
Chrissy Carroll


Full Publication List
1966-1969 1976-1979 1984-1985 1993-1994
1970-1972 1980-1981 1986-1989 1995-1998
1973-1975 1982-1983 1990-1992 1999-2004

 

1. H. E. Zimmerman, R. G. Lewis, J. J. McCullough, A. Padwa, S. Staley, and M. F. Semmelhack, J. Amer. Chem. Soc., 88, 159 (1966); "The Relation of Cyclohexenone to Cyclohexadienone Rearrangements."

2. H.E. Zimmerman, R. G. Lewis, J. J. McCullough, A. Padwa, S. Staley, and M. F. Semmelhack, J. Amer. Chem. Soc., 88, 1965 (1966); "The Relation of Cyclohexenone to Cyclohexadienone Rearrangements."

3. E. J. Corey and M. F. Semmelhack, Tetrahedron Lett., 6237 (1966); "Coupling and Cyclization of Dihalides Using Nickel Carbonyl: A One-Step Synthesis of 1,4,7-Trimethylenecyclonane from 1,1-Bis(chloromethyl)-ethylene."

4. E. J. Corey and M.F. Semmelhack, J. Amer. Chem. Soc., 89, 2755 (1967); "Organonickel Compounds as Reagents for Selective Carbon-Carbon Bond Formation Between Unlike Groups."

5. E. J. Corey, M.F. Semmelhack, and L. F. Hegedus, J. Amer. Chem. Soc.,90, 2416 (1968); "The Course of Allylic Coupling Reactions Involving Allylnickel Complexes."

6. E. J. Corey, L.F. Hegedus, and M.F. Semmelhack, J. Amer. Chem. Soc., 90, 2417 (1968); "Interconversion of Lower Valence States of π-Allyl-nickel Derivatives."

7. L.J. Altman, M.F. Semmelhack, R. B. Hornby, and J. C. Vederas, J. Chem. Soc. Chem. Comm., 686 (1968); "Photochemical Isomerization of Dimethyl 1,2-Di-hydropyridazine-1,2-dicarboxylate."

8. W. S. Johnson, M.F. Semmelhack, M. U. S. Sultanbawa, and L.A. Dolak, J. Amer. Chem. Soc., 90, 2994 (1968); "A New Approach to Steroid Total Synthesis. A Nonenzymic Biogenetic-like Olefinic Cyclization Involving the Stereospecific Formation of Five Asymmetric Centers."

9. M.F. Semmelhack and B.F. Gilman, J. Chem. Soc. Chem. Comm., 988 (1971); "Thiazepine Photochemistry: Facile 1,3-Hydrogen Shifts From a Side Chain Amide."

10. M.F. Semmelhack and S. Kunkes, and C.S. Lee, J. Chem. Soc. Chem. Comm., 698 (1971); "Thiazepine Photochemistry: The Photo-Addition of Methyl Alcohol Involving Participation by Sulfur."

11. M.F. Semmelhack and R.J. DeFranco, Tetrahedron Lett., 1061 (1971); "The Synthesis of Spiro[2.3]hexenes and a Spiro[2.3]hexadiene."

12. M.F. Semmelhack, P.M. Helquist, and L.D. Jones, J. Amer. Chem. Soc., 98, 5908 (1971); "Synthesis with Zerovalent Nickel Coupling of Aryl Halides with Bis(1,5-cyclooctadiene)nickel(0)."

13. M.F. Semmelhack, R.J. DeFranco, and J. Stock, Tetrahedron Lett., 1371 (1972); "Selective Introduction of Hydrogen Isotopes by Electrolytic Reduction of the Carbon-Halogen Bond."

14. M.F. Semmelhack, R.J. DeFranco, and J. Stock, J. Amer. Chem. Soc.,94, 2115 (1972); "The Kinetic Acidity of Spiro[2.3]hexenes and Spiro[2.3]hexadienes."

15. M.F. Semmelhack and R.J. DeFranco, J. Amer. Chem. Soc., 94, 2116 (1972); "Thermal Rearrangements of Spiro[2.3]hexenes and Spiro[2.3]hexadienes."

16. M.F. Semmelhack and G. Heinsohn, J. Amer. Chem. Soc., 94, 5139 (1972); "Selective Removal of Protecting Groups Using Electoreduction."

17. M.F. Semmelhack, B.P. Chong, and L.D. Jones, J. Amer. Chem. Soc., 94, 8629 (1972); "Total Synthesis of Cephalotaxus Alkaloids."

18. M.F. Semmelhack and R.J. DeFranco, J. Amer. Chem. Soc.,94, 8838 (1972); "Synthesis and Thermal Rearrangements of Spiro[2.3]hexadiene and Spiro[2.3]hex-4-ene Derivatives."

19. M.F. Semmelhack, J.S. Foos, and S. Katz, J. Amer. Chem. Soc., 94, 8637 (1972); "Spiro[4.4]nonatetraene and Spiro[4.4]nona-1,3,7-triene."

20. M.F. Semmelhack, P.M. Helquist, and J.D. Gorzynski, J. Amer. Chem. Soc.,94, 9234 (1972); "Synthesis with Zerovalent Nickel: Coupling of Alkenyl Halides with Bis(1,5-cyclooctadiene)-nickel(0)."

21. M.F. Semmelhack, Org. Reactions, 19, 115 (1972); "Formation of Carbon-Carbon Bonds with π-Allylnickel Compounds."

22. M.F. Semmelhack, R.J. DeFranco, Z. Margolin, and J. Stock, J. Amer. Chem. Soc., 95, 426 (1973); "Spiroaromaticity in Spiro[2.3]hexadienyl Anions: Kinetic Acidities in Highly Basic Media."

23. M.F. Semmelhack and R.D. Stauffer, Tetrahedron Lett., 2667 (1973); "Synthesis with Zerovalent Metals: Conversion of Thionocarbonates to Alkenes with Bis(1,5-cyclooctadiene)-nickel(0)."

24. M.F. Semmelhack and L. Ryono, Tetrahedron Lett., 2967 (1973); "Synthesis with Low-valent Transition Metals: Replacement of Halogen with Methyl Groups Using Methyltris(triphenylphosphine)rhodium(I)."

25. M.F. Semmelhack, R.D. Stauffer, and T.D. Rogerson, Tetrahedron Lett., 4519 (1973); "Nucleophilic Aromatic Substitution via a New Nickel- Catalyzed Process and via the S RN1 Reaction. Improved Synthesis of Cephalotaxinone."

26. M.F. Semmelhack, J.S. Foos, and S. Katz J. Amer. Chem. Soc., 95, 7325 (1973); "Spiro[4.4]nonatetraene and Spiro[4.4]non-1,3,7-triene. Synthesis and Properties. Effects of Spiroconjugation."

27. C. Batich, E. Heilbronner, E. Rommel, and M.F. Semmelhack, Helv. Chim. Acta.,56, 2110 (1973); "Bemerkung Zur Gleichheit der Aufspaltungen ∆I(Zwischen den ersten beiden π Ionizations-potentialialen) and ∆E(Zwischen den entsprechenden π*-> π Ubergansen-ergien) des Spiro[4.4]nonatetraenes."

28. C. Batich, E. Heilbronner, E. Rommel, M.F. Semmelhack, and J.S. Foos, J. Amer. Chem. Soc., 96, 7762 (1974); Equivalence of the Energy Gap I 2-I 1 and E 1-E 2 Between Corresponding Bands in the Photoelectron (I i) and Electronic Absorption (E i) Spectra of Spiro[4.4]nonatetraene: An Amusing Consequence of Spiroconjugation."

29. M.F. Semmelhack and H.T. Hall, J. Amer. Chem. Soc., 96, 7091 (1974); "Phenylation of Carbanions by π-(Chlorobenzene)chromium Tricarbonyl."

30. M.F. Semmelhack and H.T. Hall, J. Amer. Chem. Soc., 96, 7092 (1974); "Intermediates in the Reaction of Carbanions with π-(Chlorobenzene)-chromium Tricarbonyl."

31. M.F. Semmelhack , B.P. Chong, R.D. Stauffer, T.D. Rogerson, A. Chong, and L.D. Jones, J. Amer. Chem. Soc., 97, 2507 (1975); "Total Synthesis of Cephalotaxus Alkaloids. A problem in Nucleophilic Aromatic Substitution."

32. M.F. Semmelhack and L.M. Ryono, J. Amer. Chem. Soc., 97, 3873 (1975); "The Nickel-Promoted Synthesis of Cyclic Biphenyls--Total Synthesis of Alnusone Dimethyl Ether."

33. L.J. Altman, M.F. Semmelhack, R.B. Hornby, and J.C. Vederas, Org. Prep. and Proc. Int.,7, 35 (1975); "Synthesis of Dimethyl 1,2-Di- hydropyridazine-1,2-dicarboxylate."

34. M.F. Semmelhack and R.D. Stauffer, J. Org. Chem., 40, 3619 (1975); "New Preparative and Mechanistic Aspects of Copper Hydride."

35. M.F. Semmelhack, H.T. Hall, M. Yoshifuji, and G. Clark, J. Amer. Chem. Soc., 97, 1247 (1975); "Reactions of Carbanions with π-BenzenechromiumTricarbonyl. Nucleophilic Aromatic Substitution for Hydride."

36. S.M. Weinreb and M.F. Semmelhack, Accts. Chem. Res.,8, 121 (1975); "The Total Synthesis of Cephalotaxus Alkaloids."

37. M.F. Semmelhack and E.S.C. Wu, J. Amer. Chem. Soc.,98, 3384 (1976); "Synthetic Methods for the Sesquiterpene a-Methylene- g-lactones."

38. M.F. Semmelhack, M. Yoshifuji, and G. Clark, J. Amer. Chem. Soc., 98, 6387 (1976); "Cyclohexadienyltricarbonylchromium(0) Intermediates in the Reaction of Carbanions with π-Benzenechromium Tricarbonyl."

39. M.F. Semmelhack in New Applications of Organometallic Reagents in Organic Synthesis, D. Seyferth, ed., Elsevier, 1976, p. 361; "Arene-Metal Complexes in Organic Synthesis."

40. M.F. Semmelhack, H. Weller, and J. Foos, J. Amer. Chem. Soc., 99, 292 (1977); "Thermal Rearrangements of Spiro[4.4]nonapolyenes. Usually Rapid 1,5-Vinyl Migration."

41. M.F. Semmelhack, L. Keller, and Y. Thebtaranonth, J. Amer. Chem. Soc., 99, 959 (1977); "Formation of Fused, Spiro, and Metacyclophane Rings via Intermolecular Carbanion Attack on Arene-Chromium Complexes."

42. M.F. Semmelhack and G. Clark, J. Amer. Chem. Soc.,99, 1675 (1977); "Meta-substituted Aromatics by Carbanion Attack on π-Anisole and π-Toluenechromium Tricarbonyl."

43. M.F. Semmelhack and T. Bargar, J. Org, Chem.,42, 1481 (1977); "Cyclizations of Enolates onto Aromatic Rings via the Photo-S RN1 Reaction. Preparative and Mechanistic Aspects."

44. M.F. Semmelhack and J.C. Tomesch, J. Org. Chem., 42, 2657 (1977); "Grob-type Fragmentation of Five and Six-membered Rings Promoted by Cuprous Ion."

45. M.F. Semmelhack, R.D. Stauffer, and A. Yamashita, J. Org. Chem., 42, 3180 (1977); "Reduction of Conjugated Carbonyl Compounds with Copper Hydride - Preparative and Mechanistic Aspects."

46. M.F. Semmelhack, Annals New York Acad. Sci., 295, 36 (1977); "Arene-Metal Complexes in Organic Synthesis."

47. M.F. Semmelhack, J.C. Tomesch, M. Czarny, and S. Boettger, J. Org. Chem., 43, 1259 (1978); Preparation of 2-(Alkylthiomethyl)acrylates."

48. M.F. Semmelhack, A. Yamashita, J.C. Tomesch, and K. Hirotsu, J. Amer. Chem. Soc., 100, 5565 (1978); "Total Synthesis of Confertin via Metal-Promoted Cyclization-Lactonization."

49. M.F. Semmelhack, H.N. Weller, and J. Clardy, J. Org. Chem., 43, 3791 (1978); "Rapid Vinyl Shifts in Spiro[4.4]polyenes. Verification of the Rate-Determining Step and Identity of the Migrating Group."

50. M.F. Semmelhack, G. Clark, R. Farina, J. Amer. Chem. Soc., 101, 217 (1979); "Substituent Effects in Addition of Carbanions to Arene-chromium Tricarbonyl Complexes: Correlation with Arene LUMO."

51. M.F. Semmelhack, J. Bisaha, and M. Czarny, J. Amer. Chem. Soc., 101, 768 (1979); "Metalation of Arene-Chromium Tricarbonyl Complexes and Electrophilic Trapping of the Complexed Phenyllithium Intermediate."

52. M.F. Semmelhack, H.T. Hall, Jr., R. Farina, M. Yoshifuji, G. Clark, T. Barger, K. Hirotsu, and J. Clardy, J. Amer. Chem. Soc.,101, 353 (1979); " h 5-Cyclohexadienyl-tricarbonylchromium(0) Complexes from Addition of Carbon Nucleophiles to h 6-Benzene-tricarbonylchromium(0). Formation, Chemical and Spectroscopic Features, and X-ray Diffraction Analysis."

53. M.F. Semmelhack, J. J. Harrison, and Y. Thebtaranonth, J. Org. Chem., 44, 3275 (1979); "Formation of 3-Substituted Cyclohexenones by Nucleophilic Addition to Anisole-Chromium Complexes."

54. M.F. Semmelhack and T. Bargar, J. Amer. Chem. Soc., 102, 7765 (1980); "Photostimulated Nucleophilic Aromatic Substitution for Halides with Carbon Nucleophiles. Preparative and Mechanistic Aspects."

55. M.F. Semmelhack and A. Yamashita, J. Amer. Chem. Soc., 102, 5924 (1980); "Arene-Metal Complexes in Organic Synthesis. Synthesis of Acorenone and Acorenone B."

56. M.F. Semmelhack, W. Seufert, and L. Keller, J. Amer. Chem. Soc., 102, 6584 (1980); "Arene-Metal Complexes in Organic Synthesis: Addition to Styrene-type Ligands."

57. M.F. Semmelhack, S. Tomoda, and K. Hurst, J. Amer. Chem. Soc., 102, 7567 (1980); "Synthesis of Illudol."

58. M.F. Semmelhack and Steve J. Brickner, J. Org. Chem., 46, 1723 (1981); "Intramolecular Carbonylation of Vinyl Halides to Form Methylene Lactones."

59. M.F. Semmelhack and Shuji Tomoda, J. Amer. Chem. Soc.,103, 2427 (1981); "Synthesis of ()-Fomannosin."

60. M.F. Semmelhack and Steve J. Brickner, J. Amer. Chem. Soc., 103, 3945 (1981); "Nickel-Promoted Cyclization/Carbonylation in the Preparation of a-Methylene- g-Lactones: Stereospecific Synthesis of ()-Frullanolide."

61. M.F. Semmelhack, G. Clark, J.L. Garcia, J. Harrison, Y. Thebtaranonth, W. Wulff, and A. Yamashita, Tetrahedron, 37, 3957 (1981); "Addition of Carbon Nucleophiles to Arene-Chromium Complexes."

62. M.F. Semmelhack, Pure Appl. Chem., 534, 2379 (1981); "Nucleophilic Addition to Diene and Arene-Metal Complexes."

63. M.F. Semmelhack, P. Helquist, L.D. Jones, L. Keller, L. Mendelson, L. Ryono, J. Gorzynski, and R. Stauffer, J. Amer. Chem. Soc.,103, 6460 (1981); "Reaction of Aryl and Vinyl Halides with Zerovalent Nickel: Preparative and Mechanistic Aspects, and the Synthesis of Alnusone."

64. M.F. Semmelhack in Organic Synthesis: Today and Tomorrow, Pergamon Press, 1981, p. 64; "Arene-Metal Complexes in Organic Synthesis."

65. J. Schwartz and M. F. Semmelhack, Chimia, 1981, 35, 291; "Rational Design of Transition Metal Reagents for Organic Synthesis."

66. M.F. Semmelhack, S. Tomoda, H. Nagaoka, Susan D. Boettger, and Kenneth M. Hurst, J. Amer. Chem. Soc.,104, 747 (1982); "Synthesis of Racemic Fomannosin and Illudol Using a Biosynthetically Patterned Common Intermediate."

67. M.F. Semmelhack, W. Seufert, and L. Keller, J. Organomet. Chem., 226, 183 (1982); "Arene-Metal Complexes: Preparation and Reaction of h 6-Arene-Cr(C0) 2(diphos) and Analogs."

68. M.F. Semmelhack and R. Misra, J. Org. Chem., 47, 2469 (1982); "Stereo-selective Ketone Reductions: Reduction of 4-t-Butylcyclo-hexanone by Alkylsilanes in the Presence of Rh(I) and Ru(II) Catalysts."

69. M.F. Semmelhack and Joseph J. Bozell, Tetrahedron Lett., 23, 2931 (1982); "Naphthoquinones from Alkynes and Chromium-Carbene Complexes - Control of Regioselectivity Through Intramolecular Reaction."

70. M.F. Semmelhack and Christina Ullenius, J. Organomet. Chem.,235, C10-C12 (1982); "On the Stability and Decomposition of h 6-(2-Lithiochlorobenzene)tricarbonyl-chromium(0)."

71. M.F. Semmelhack, J.J. Bozell, T. Sato, W. Wulff, E. Spiess, and A. Zask, J. Amer. Chem. Soc.,104, 5850 (1982); "Synthesis of Nanaomycin A and Deoxyfrenolicin by Alkyne Cyclo-addition to Chromium-Carbene Complexes."

72. M.F. Semmelhack, L. Keller, T. Sato, and E. Spiess, J. Org. Chem., 47, 4382 (1982); "Synthesis of Naphthoquinone Antibiotics: Conjugate Addition/Electrophile Trapping with Acylnickel Carbonylate Anions."

73. M.F. Semmelhack, W. Wulff, and J.L. Garcia, J. Organomet. Chem.,240, C5-C10 (1982); "New Substitution Reactions on Indole Promoted by the Cr(CO) 3 Unit."

74. W.R. Jackson, I.D. Rae, M.G. Wong, M.F. Semmelhack, and J.L. Garcia, J. Chem. Soc. Chem. Comm., 1359 (1982); "Stereoelectronic Control of the Regioselectivity of both Electrophilic and Nucleophilic Substitution of h 6-(1,1-Dimethylindane)-tricarbonylchromium(0)."

75. M.F. Semmelhack, T. Sato, J.J. Bozell, L. Keller, W. Wulff, A. Zask, and E. Spiess, Current Trends in Organic Synthesis, Hitosi Nozaki, Ed., Pergamon Press, New York; "Quinone Synthesis with Organometallic Reagents."

76. M.F. Semmelhack and A. Zask, J. Amer. Chem. Soc., 105, 2034 (1983); "Synthesis of Racemic Frenolicin Via Organochromium and Organopalladium Intermediates."

77. M.F. Semmelhack, J.W. Herndon, J.P. Springer, J. Amer. Chem. Soc.,105, 2497 (1983); "Nucleophile Addition/Carbonylation with h 6-Dienetri-carbonyliron(0) Complexes."

78. M.F. Semmelhack and James W. Herndon, Organomet.,2, 363 (1983); "Scope of Anion Addition to h 4-(1,3-Cyclohexadiene)tricarbonyliron(0)."

79. M.F. Semmelhack, J.L. Garcia, D. Cortes, R. Farina, R. Hong, and B.K. Carpenter, Organomet., 2, 467 (1983); "Nucleophilic Addition to ( h 6-Alkylbenzene)Cr(CO) 3 Complexes. Dependence of Regioselectivity on the Size of the Alkyl Group and the Reactivity of the Nucleophile."

80. M.F. Semmelhack and Rui Tamura, J. Amer. Chem. Soc., 105, 4099 (1983); "Control Over Site of Alkylation in Iron Acylate Complexes: General Preparation and Reactions of Alkylidene-Iron Tetracarbonyl Complexes."

81. M.F. Semmelhack, C.S. Chou, and D.A. Cortes , J. Amer. Chem. Soc., 105, 4492 (1983); "Nitroxyl-Mediated Electro-oxidation of Alcohols to Aldehydes and Ketones."

82. M.F. Semmelhack and C.R. Schmid, J. Amer. Chem. Soc.,105, 6732 (1983); "Nitroxyl-Mediated Electro-oxidation of Amines to Nitriles and Carbonyl Compounds."

83. M.F. Semmelhack, J.W. Herndon, and J.K Liu, Organomet.,2, 1885 (1983); "Cyclopentanones from Nucleophile Addition/Carbonylation to h 4-(Diene)Fe(CO) 3 Complexes."

84. M.F. Semmelhack and Rui Tamura, J. Amer. Chem. Soc., 105, 6750 (1983); "Coupling of Alkenes with Fischer-type Alkylidene Complexes of Iron."

85. M.F. Semmelhack and C. Bodurow, J. Amer. Chem. Soc.,106, 1496 (1984); "Intramolecular Alkoxypalladation/Carbonylation of Alkenes."

86. M.F. Semmelhack and J.W. Herndon, J. Organomet. Chem., 265, C15 (1984); "New Iron Complexes from Nucleophile Addition/Carbonylation of h 4-(1,3-Diene)tricarbonyliron(0) Complexes."

87. M.F. Semmelhack and H.T.M. Le, J. Amer. Chem. Soc.,106, 2715 (1984); "Regio-selectivity and Rearrangement Upon Addition of Nucleophiles to Diene-Iron Complexes."

88. M.F. Semmelhack, C.R. Schmid, D.A. Cortes, and C.S. Chou, J. Amer. Chem. Soc.,106, 3374 (1984); "Oxidation of Alcohols to Aldehydes with Oxygen and Cupric Ion, Mediated by Nitrosonium Ion."

89. M.F. Semmelhack, C. Bodurow, and M. Baum, Tetrahedron Lett., 3171 (1984). "Direct Synthesis of Pyran-lactones Related to Naphthoquinone Antibiotics."

90. M.F. Semmelhack, R. Tamura, W. Schnatter, and J. Springer, J. Amer. Chem. Soc.,106, 5363 (1984); "Reaction of Alkynes with (Ethoxyalkylidene)-tetracarbonyliron(0) with Alkenes and Alka-1,3-dienes."

91. M.F. Semmelhack and J.L Garcia, Inorganic Reactions and Methods, J.J. Zuckerman, ed., 1984; "Formation of Cyclohexadienyl Complexes by Nucleophilic Addition to Arene-Metal Complexes."

92. M.F. Semmelhack and J.L Garcia, Inorganic Reactions and Methods, J.J. Zuckerman, ed., 1984; "Formation of Arene-Metal Complexes by Ligand Displacement."

93. M.F. Semmelhack, "The Synthesis of Fomannosin and Illudol" in "Strategies and Tactics or Organic Synthesis," T. Lindberg, ed., Academic Press, New York, 1984.

94. M.F. Semmelhack, "Regioselectivity in Metal-promoted Carbon-Carbon Coupling Reactions" - A Goal for Synthetic Efficiency," W. Bartmann and B.M. Trost, eds. Verlag-Chemie, 1984.

95. M.F. Semmelhack, C.M. Bodurow, E. Fewkes, J.W. Herndon, G. Knaus, H.T.M. Le, and M. Sanner, Chimica Scripta, 25, 131 (1985); "Stereoselectivity in Metal-Promoted Coupling Reactions of Nucleophiles with Alkenes and Alka-1,3-dienes."

96. M.F. Semmelhack, J.J. Bozell, L. Keller, T. Sato, E.J. Spiess, W. Wulff, and A. Zask, Tetrahedron,41, 5803 (1985); "Synthesis of Naphthoquinone Antibiotics by Intramolecular Alkyne Cycloaddition to Carbene-Chromium Complexes."

97. M.F. Semmelhack and Hanh T.M. Le, J. Amer. Chem. Soc., 107, 1455 (1985); "Transient Ferracyclobutanes during Protonation of h 3-Homoallyliron(0) Complexes."

98. M.F. Semmelhack, Y. Appapillai, and T. Sato, J. Amer. Chem. Soc. ,107, 4577 (1985); "Stereospecific Synthesis of the Bicyclo[2.2.2] Portion of Granaticin: Synthesis of Sarubicin A."

99. M.F. Semmelhack, J.J. Harrison, D.C. Young, A. Gutierrez, S. Rafii, and J. Clardy, J. Amer. Chem. Soc., 107 (1985); "[3.3]Metacyclophane: A Novel Synthesis and A Study of the Structure Through X-Ray Diffraction, Molecular Mechanics, and Solution NMR Analysis."

100. M.F. Semmelhack, L. Keller, T. Sato, E.J. Spiess, and W. Wulff, J. Org. Chem.,50, 5566 (1985); "Conjugate Addition of Acylate-Nickel Complexes to Quinone Monoketals: Formal Synthesis of the Naphthoquinone Antibiotics Nanaomycin A and Deoxyfrenolicin."

101. M. F. Semmelhack Tetrahedron, 1985, 41, R13. "Application of Newer Organometallic Reagents to the Total Synthesis of Natrual Products--Preface."

102. M.F. Semmelhack, R. Tamura, W. Schnatter, J. Park, M. Steigerwald, and S. Ho, "Carbene-Metal Complexes--New Processes and Applications in Organic Synthesis, " Proceedings of 2nd International Kyoto Conference on Organic Chemistry, S. Yamada, ed., 1985.

103. M.F. Semmelhack, Christopher R. Schmid and David Cortes, Tetrahedron Lett., 1119, 27 (1986); "Mechanism of the Oxidation of Alcohols by 2,2,6,6-Tetramethylpiperidine Nitrosonium-Cation."

104. M.F. Semmelhack and Jaiwook Park, Organometallics,5, 2550 (1986); "Reaction of (Aminocarbene) Iron Complexes with Alkynes: A Synthesis of 5-Aminofurans."

105. M.F. Semmelhack, R. Tamura, W. Schnatter, Jaiwook Park, M. Steigerwald, and Suzzy Ho, New Aspects of Organic Chemistry,"Proceedings of the Third International Kyoto Conference on Organic Chemistry. "Carbene-Metal Complexes--New Processes and Applications in Organic Synthesis," March, 1986.

106. M.F. Semmelhack, Jaiwook Park, W. Schnatter, R. Tamura, and M. Steigerwald, Chimica Scripta,27, 509-510 (1987); "Coupling Reactions of Fischer-type Carbene Complexes of Iron."

107. M.F. Semmelhack and Jaiwook Park, J. Am. Chem. Soc., 109, 935 (1986); "Coupling of 1,3-Dienes with (Carbene)iron Complexes to Give Substituted (1,3-Diene)Fe(CO) 3 Derivatives."

108. M.F. Semmelhack and G.R. Lee, Organometallics, 6, 1839 (1987); "Preparation of Acylpentacarbonylchromate Salts and Alkoxycarbene Pentacarbonyl Complexes of Chromium Employing the Pentacarbonylchromate Dianion ([Cr(CO) 5] -2)."

109. M.F. Semmelhack and E.J. Fewkes, Tetrahedron Lett., 28, 1497 (1987); "De-Protonation of h 4-Isoprene)Fe(CO) ; An Isoprene Anion Equivalent."

110. M.F. Semmelhack, Suzzy Ho, M. Steigerwald, and M.C. Lee, J. Amer. Chem. Soc., 109, 4397 (1987); "Metal Carbonyl Promoted Rearrangement of Cyclopropenes to Naphthols."

111. M. F. Semmelhack, J. Park, W. Schnatter, R. Tamura, and M. Steigerwald, Chimica Scripta, 27, 509 (1987); "Coupling Reactions of Fischer-type Carbene Complexes of Iron."

112. M. F. Semmelhack and P. M. Helquist, Org. Synth., 1988, 50, 722. "Reaction of Aryl Halides with Pi-Allyl Nickel Halides--Methallylbenzene."

113. M. F. Semmelhack, C. R. Kim, W. Dobler, and M. Meier, Tetrahedron Lett., 30, 4925 (1989); "Controlled beta-Hydride Elimination During Tetrahydrofuran Formation with Pd(II). Diastereoselective Formation of the Tetrahydropyran Ring of Tetronomycin."

114. M. F. Semmelhack and N. Zhang, J. Org. Chem., 54, 4483 (1989); "Stereoselective Formation of Tetrahydrofuran Rings via Intramolecular Alkoxycarbonylation of Hydroxyalkenes."

115. D. H. Boscheli, D. Powell, V. Sharky, and M. F. Semmelhack, Tetrahedron Lett., 30, 1243 (1989); "An Improved Synthesis of Glycinamide Ribonucleotide."

116. M. F. Semmelhack and N. Jeong, Tetrahedron Lett., 31, 605 (1990); "Approach to the Synthesis of Nogalarol via the Cycloaddition of a Carbene-chromium complex with a Functionalized Alkyne."

117. M. F. Semmelhack, N. Jeong, and G. R. Lee, Tetrahedron Lett., 31, 609 (1990); "The Effect of Propargyl Oxygen Substitutes in the Carbene-Chromium Alkyne Cycloaddition."

118. M. F. Semmelhack, J. Gallagher, and D. Cohen, Tetrahedron Lett., 31, 1521 (1990); "Bioreductive Alkylation as a Trigger for the Toxic Effects of Dynemicin."

119. C. A. Merlic and M. F. Semmelhack, J. Organomet. Chem., 391, C23 (1990); "An Interesting Chloride Ion Effect in the Heck Reaction."

120. M. F. Semmelhack, C. Kim, N. Zhang, C. Bodurow, M. Sanner, W. Dobler, and M. Meier, Pure & Appl. Chem, 62, 2035 (1990); "Intramolecular Alkoxy-carbonylation of Hydroxy Alkenes Promoted by Pd(II)".

121. M. F. Semmelhack and C. H. Cheng, J. Organomet. Chem ,393, 237 (1990); "A New Method for the Synthesis of Iron Azadiene and Diene Complexes. Reaction of ( h 2-RCHCHCOR') Fe(CO) 4 with Aniline and Ylide".

122. M. F. Semmelhack, Chem. Eng. News 1990, 68, 2. "Structure of Dynamemicin."

123. M. F. Semmelhack, T. Neu, and F. Foubelo, Tetrahedron Lett., 33, 3277 (1992); "Arene 1,4-Diradical Formation from o-Dialkynylarenes."

124. M. F. Semmelhack, in "Comprehensive Organic Synthesis," B. Trost and I Fleming, Eds., Vol. 4, 1992, p 409, "Nucleophilic Addition to Arene-Metal Complexes."

125. M. F. Semmelhack and H. Rhee, Tetrahedron Lett., 34, 1395 (1993); "A Synthesis of (-)-Indolactam V."

126. M. F. Semmelhack and H. Rhee, Tetrahedron Lett., 34, 1399 (1993); "Formal Synthesis of Teleocidin A via Indole-Cr(CO) 3 Complexes."

127. M. F. Semmelhack and J. J. Gallagher, Tetrahedron Lett., 34, 4121 (1993); "Cyclic Conjugated Enediynes via Elimination of a Thionocarbonate in a Latent Z-Hex-3-ene-1,5-diyne Unit"

128. M. F. Semmelhack and W. Epa, Tetrahedron Lett., 34, 7205 (1993); "Catalytic Tandem Oxy-Palladation and Vinylation."

129. M. F. Semmelhack, P. Knochel, and T. Singleton, "Tetrahedron Lett., 34, 5051; "A New Approach to Indole Alkaloids via Indole Chromium Complexes,

130. M. F. Semmelhack, T Minami, T. Sato, and J. J. Gallagher, J. Amer. Chem. Soc., 115, 11618 (1993); "The Enol-Keto Trigger in Initiating Arene Diradical Formation in Calicheamicin/Esperimicin Analogs."

131. M. F. Semmelhack J. J. Gallagher, W.-d. Ding, G. Krishnamurthy, R. Babine, and G. A. Ellestad, J. Org. Chem., 59, 4357 (1994); "The Effect on DNA Cleavage Potency of Tethering a Simple Cyclic Enediyne to a Netropsin Analog."

132. M. F. Semmelhack; T. Neu; F. Foubelo, J. Org. Chem., 59, 5038 (1994); "Arene 1,4-Diradical Formation from o-Dialkynylarenes."

133. R. E. Babine, N. Zhang, S. R. Schow, Z. Xu, R. A. Byrn, R. C. Hastings, M. F. Semmelhack, M. M. Wick, and S. S. Kewar, Bioorganic and Medicinal Lett., 4, 583 (1994); "Design, Structure, Activity, and X-ray Crystallographic Studies of Pseudo-symmetrical Nonpeptidyl HIV-1 Protease Inhibitors."

134. R. E. Babine; N. Zhang; A, Jurgens; S. Schow; P. R. Desai; J. C. James; M. F. Semmelhack, Bioorganic and Medicinal Lett., 2, 541 (1992); "The Use of HIV-I Protease Structure in Inhibitor Design."

135. Andrea Goti; M. F. Semmelhack J. Organomet. Chem., 470, C4 (1994); "Unusually Mild Arene Ligand Attachment Using ( h 5-N-Methylpyrrole)Tricarbonyl Chromium(0)"

136. M. F. Semmelhack, S. Ho, D. Cohen, M. Steigerwald, G. Lee, A. M. Gilbert, W. D. Wulff, and R. G. Ball, J. Amer. Chem. Soc., 116, 7108 (1994); "Metal-Catalyzed Cyclopropene Rearrangements for Benzannulation; Evaluation of an Anthraquinone Synthesis Pathway and Re-evaluation of the Parallel Approach via Carbene-Chromium Complexes."

137. M. F. Semmelhack, W. Epa, A. Cheung, Y. Gu, C. Kim, N. Zhang, and W. Lew, J. Amer. Chem. Soc., 116, 7455 (1994); "Palladium-Promoted Synthesis of Ionophore Antibiotics. Strategy and Assembly of the Homochiral Tetrahydrofuran and Tetrahydropyran Portions of Tetronomycin"

138. M. F. Semmelhack, in "Comprehensive Organometallic Chemistry" 2nd Ed., Volume 12 "Transition Metals in Organic Synthesis," L. Hegedus, ed, Pergamon Press, Oxford, 1995, p 979; "Transition Metal Arene Complexes: Nucleophilic Addition.".

139. M. F. Semmelhack, in "Comprehensive Organometallic Chemistry" 2nd Ed., Volume 12 "Transition Metals in Organic Synthesis," L. Hegedus, ed., Pergamon Press, Oxford, 1995, p 1017; "Transition Metal Arene Complexes: Ring Lithiation."

140.M. F. Semmelhack, in "The Encyclopedia of Inorganic Chemistry," Organometallic Section, Chapter 31., C. M. Lukehart, ed., John Wiley, New York, 1996. "Organic Synthesis: Transition Metal Complexes Containing Pi-Bonded Ligands."

141. M. F. Semmelhack and H.-G. Schmalz, Tetrahedron Lett., 37, 3089 (1996); "Asymmetric Induction in The Nucleophiile Addition to h 6-Arene-Tricarbonyl-Chromium(0) Complexes."

142. M. F. Semmelhack, Yansong Gu, and D. M. Ho, Tetrahedron Lett., 38, 5583 (1997). "A New Framework for the Cycloaromatization of Enediynes Under Mild Conditions."

143. M. F. Semmelhack, G. Hilt, and J. H. Colley, Tetrahedron Lett., 39, 7683 (1998). "S NAr Reactions with Fluoroarene-Cr(CO) 2L Complexes, where L is a Potential Linker Ligand for Solid Phase Synthesis."

144. M. F. Semmelhack and P. Shanmugam, Tetrahedron Lett., 41, 3567 (2000). "Development of an Approach to the Synthesis of the Plakortones."

145. Semmelhack, M. F.; Sarpong, R. Abs. Am. Chem. Soc., 2000, 219, p 76-MEDI. "Kinetics of Rearrangment of a Model Enediyne."

146. Semmelhack, M. F.; Hilt, G. Syn. Lett., 2000, 1127. "Selective Functionalization of an Isodurene-Cr(CO) 3 Complex.

147. Semmelhack, M. F.; Jiang, Yu; and Ho, Douglas , Org. Lett. 2001, 3, 2403. "Synthesis of the Amino Sugar from C-1027"

148. Semmelhack, M. F.; Chlenov, A.; Wu, Lingyun, J. Am Chem. Soc., 2001, 123, 8438. "Accelerated Arene Ligand Exchange in AreneCr(CO) 3 Complexes."

149. Semmelhack, M. F.; Lindenschmidt, A.; Ho, D. M. Organometallics, 2001, 20, 4114. "Preparation and Structure of Chiral Carbene Complexes of manganese and Iron from Terminal alkynes."

150. Semmelhack, M. F.; Sarpong, R.; Bergman, J. Ho, D. M. Tetrahedron Lett., 2002, 43, 541. "Evaluation of Alkene isomerization as a Trigger for enediyne Activation."

151. Kipp, R. A.; Case, M. A.; Wist, A. D.; Cresson, C. M.; Carrel, M.; Griner, E.; Wiita, A.; Albiniak, P. A.; Chai, J.; Shi, Y.; Semmelhack, M. F.; McLendon, G. L. Biochem. 2002, 41, 7344-7349. "Molecular Targeting of Inhibitor of Apoptosis Proteins Based on Small Molecule Mimics of Natural Binding Partners."

Semmelhack, M. F.; Jaskowski, M.; Sarpong, R.; Ho, D. M. Tetrahedron Lett. 2002, 43, 4947-4950. "A Simple Synthesis and Evaluation of the Bicyclo[8.3.0] Enediyne Framework."

153. Semmelhack, M. F.; Hooley, R. J. Tetrahedon Lett.,2003, 44, 5737-5739. “Palladium-Catalyzed Hydrostannylations Of Highly Hindered Acetyolenes In Hexane.”

154. Semmelhack, M. F.; Wu, Lingyun; Pascal, R. P.; Ho, Douglas M. J. Am. Chem. Soc., 2003, 125, 10496-10497 “Conformational Control in Activation of an Enediyne.”

155. Semmelhack, M. F.; Campagna, S. r.; Hwa, C.; Federle, M. J.; Bassler, B. L. Org. Lett., 2004, 6, 2635-2637. “Boron Binding with the Quorum Sensing Signal AI-2 and Analogues.”

156. Semmelhack, M. F.; Sarpong, R. J. Phys. Org. Chem., 2004, 17, 807-813. “Kinetic Analysis of a Reactive Model Enediyne.”

157. Miller, S. T.; Xavier, K. B.; Campagna, S. R.; Taga, M. E.; Semmelhack, M. F.; Bassler, B., L.; Hughson, F. M. Molecular Cell, 2004, 15, 677-687. “Salmonella typhimurium Recognizes a Chemically Distinct Form of the Bacterial Quorum-Sensing Signal AI-2.”

158. Semmelhack, M. F.; Chlenov, A. “AreneCr(CO) 3 Complexes: Arene Lithiation/Rea ction with Electrophiles.” in “Transition Metal Arene Pi Complexes in Organic Synthesis and Catalysis.” Kundig, E. P. ed.; Springer-Verlag, Berlin, 2004, pp 21-42.

159. Semmelhack, M. F.; Chlenov, A. “AreneCr(CO) 3 ComplexesAromatic Nucleophilic Substitution.” in “Transition Metal Arene Pi Complexes in Organic Synthesis and Catalysis.” Kundig, E. P. ed.; Springer-Verlag, Berlin, 2004, pp 43-70.

Chemistry Department