CBE 201

An Introduction to Scientific Computing

Professor/Instructor

Athanassios Z. Panagiotopoulos

An introduction to computer programming emphasizing numerical modeling and problem solving, including numerical integration, solution of systems of non-linear equations, and composition of high-level macros for numerical work within spreadsheets. The programming environment is Visual Basic.NET, an object-oriented programming language that is accessible to beginner programmers and permits the rapid development of applications with a graphical user interface. Utilizes MATLAB data analysis, visualization, programming, and symbolic mathematics systems. Two lectures, one preceptorial. Prerequisite: MAT 103.

MOL 215 / EEB 215 / CBE 215

Quantitative Principles in Cell and Molecular Biology

Professor/Instructor

Alexei V. Korennykh, Jared E. Toettcher, Philip George Felton

Central concepts and experiments in cellular, molecular, and developmental biology with an emphasis on underlying physical and engineering principles. Topics include the genetic code; energetics and cellular organization; communication, feeding, and signaling between cells; feedback loops and cellular organization; problems and solutions in development; the organization of large cellular systems, such as the nervous and immune systems. Satisfies the biology requirement for entrance into medical school. Prerequisites: AP biology, physics, and calculus. Three lectures, one three-hour laboratory.

MAE 228 / EGR 228 / CBE 228 / ENE 228

Energy Technologies in the 21st Century

Professor/Instructor

Jay Burton Benziger

Addresses issues of regional and global energy demands, including sources, carriers, storage, current and future technologies, costs for energy conversion, and their impact on climate and the environment. Also focuses on emissions and regulations for transportation. Students will perform cost-efficiency and environmental impact analyses from source to end-user on both fossil fuels and alternative energy sources. Designed for both engineering and non-engineering concentrators. Two 90-minute lectures, one preceptorial.

CBE 245

Introduction to Chemical and Biochemical Engineering Principles

Professor/Instructor

Mark Philip Brynildsen

Application of the principles of conservation of mass and energy to the design and analysis of chemical processes. Elementary treatment of single and multiphase systems. First law of thermodynamics for closed and open systems. Steady state and transient analysis of reacting and nonreacting systems. Two lectures, one preceptorial. Prerequisite: CHM 201.

CBE 246

Thermodynamics

Professor/Instructor

Ilhan A. Aksay

Basic concepts governing the equilibrium behavior of macroscopic fluid and solid systems of interest in modern chemical engineering. Applications of the first law (energy conservation) and second law (temperature, entropy, reversibility) to open and closed systems. Thermodynamic properties of pure substances and mixtures. Phase equilibrium and introduction to reaction equilibrium. Introduction to the molecular basis of thermodynamics. Applications include thermodynamics of protein stability, the Earth's energy balance, energy conversion schemes, and the binding of ligands to proteins. Prerequisites: CBE 245 and MAT 201.

CBE 250

Separations in Chemical Engineering and Biotechnology

Professor/Instructor

Robert Krafft Prud'homme

Fundamental thermodynamic principles and transport processes that govern separations in biotechnology and chemical processing. Staged operations, such as distillation and chromatography, are developed based on coupling phase equilibrium with mass balances. Transport processes driven by electric fields, centrifugal fields, or hydrodynamics provide the basis for understanding ultracentrifugation, membrane process, and electrophoresis. Three lectures. Prerequisites: CBE 245 and CBE 246. MAE 305 and CHM 303 may be taken concurrently.

CBE 260 / EGR 260

Ethics and Technology: Engineering in the Real World

Professor/Instructor

Jay Burton Benziger

An examination of engineering as a profession and the professional responsibilities of engineers. The ethics of engineering will be considered through case studies (e.g., automobile safety, pollution control), and the social responsibilities of engineering will be distinguished from those of science and business. Quantitative decision-making concepts, including risk-benefit analysis, are introduced and weighed against ethical considerations to compare technology options. Ethical conflicts between utilitarian theories and duty theories will be debated. Two lectures, one preceptorial, one film class.

MAE 305 / MAT 391 / EGR 305 / CBE 305

Mathematics in Engineering I

Professor/Instructor

Stanislav Yefimovic Shvartsman, Howard A. Stone

An introduction to ordinary differential equations. Use of numerical methods. Equations of a single variable and systems of linear equations. Method of undermined coefficients and method of variation of parameters. Series solutions. Use of eigenvalues and eigenvectors. Laplace transforms. Nonlinear equations and stability; phase portraits. Partial differential equations via separation of variables. Sturm-Liouville theory. Three lectures. Prerequisites: MAT 201 or 203, and MAT 202 or 204, or MAE 303.

CBE 341

Mass, Momentum, and Energy Transport

Professor/Instructor

Pierre-Thomas Brun

Survey of modeling and solution methods for the transport of fluids, heat, and chemical species in response to differences in pressure, temperature, and concentration. Steady state and transient behavior will be examined. Topics include fluid statics; conservation equations for mass, momentum and energy; dimensional analysis; viscous flow at high and low Reynolds number; thermal conduction; convective heat and mass transfer, correlations; diffusion and interphase mass transfer. Working knowledge of calculus, linear algebra and ordinary differential equations is assumed. Prerequisites: CBE 245, CBE 246 & MAE 305. Can take MAE 305 concurrently.

CBE 342

Fluid Mechanics

Professor/Instructor

Sankaran Sundaresan

Elements of fluid mechanics relevant to simple and complex fluids. Topics include macroscopic balances; derivation of differential balance equations and applications to unidirectional flows; treatment of nearly unidirectional flows through the lubrication approximation; introduction to turbulent flow; flow through porous media; capillary flows; dispersed two-phase flows; and hydrodynamic stability. Three lectures. Prerequisite: CBE 341.

CBE 346

Chemical Engineering Laboratory

Professor/Instructor

Sankaran Sundaresan, Clifford Paul Brangwynne, Bruce E. Koel

An intensive hands-on practice of engineering. Experimental work in the areas of separations, heat transfer, fluid mechanics, process dynamics and control, materials processing and characterization, chemical reactors. Development of written and oral technical communication skills. One lecture, two three-hour laboratories. Prerequisites: CBE 246 and CBE 341 or equivalents.

CBE 351

Junior Independent Work

Professor/Instructor

A. James Link

Subjects chosen by the student with the approval of the faculty for independent study. A written report, examination, or other evidence of accomplishment will be required.

CBE 352

Junior Independent Work

Professor/Instructor

A. James Link

Subjects chosen by the student with the approval of the faculty for independent study. A written report, examination, or other evidence of accomplishment will be required.

CBE 415 / CHM 415 / MSE 425

Polymers

Professor/Instructor

Richard Alan Register

Broad introduction to polymer science and technology, including polymer chemistry (major synthetic routes to polymers), polymer physics (solution and melt behavior, solid-state morphology and properties), and polymer engineering (overview of reaction engineering and melt processing methods). Three lectures. Prerequisites: CHM 301 or 303, which may be taken concurrently, and MAT 104, or permission of the instructor.

CBE 421 / CHM 421 / ENE 421

Catalytic Chemistry

Professor/Instructor

Jay Burton Benziger

Concepts of heterogeneous catalysis applied to chemical processes. Major industrial processes based on heterogeneous catalysis, including ammonia synthesis, partial oxidation, petroleum refining, and environmental control. The major classes of heterogeneous catalysts, such as solid acids and transition metals, and the classes of chemical reactions catalyzed by these materials. Processing conditions and reactor design are considered. Fundamentals of surface reactivity will be explored. Two lectures. Prerequisite: CHM 303 organic chemistry.

CBE 423

Biologically Inspired Materials

Professor/Instructor

Ilhan A. Aksay

Focuses on the pathways utilized by biological systems to produce hierarchically structured inorganic/organic nanocomposites such as bone, teeth, diatoms, and sea-shells. These structures form through template-assisted self-assembly, in which self-assembled organic materials (proteins, lipids, or both) serve as the structural scaffolding. The outcome is multifunctional composites with self-healing, sensing, and actuating properties. The course will critically evaluate the potential of biologically inspired materials in future applications. Two lectures, one preceptorial.

CBE 432

The Cell as a Chemical Reactor

Professor/Instructor

Stanislav Yefimovic Shvartsman

Presents a framework for the analysis of cellular responses, such as proliferation, migration, and differentiation. Emphasis on mechanistic models of biotransformation, signal transduction, and cell-cell communication in tissues. Focuses first on unit operations of cell physiology transcription, translation, and signal transduction. Models of these processes will rely on tools of reaction engineering and transport. Process dynamics and control will then be used to analyze the regulatory structure of networks of interacting genes and proteins. One lecture. Prerequisites: MOL 214 and MAE 305 or their equivalents.

MOL 433 / CBE 434 / GHP 433

Biotechnology

Professor/Instructor

Jane Flint

This course will consider the principles, development, outcomes and future directions of therapeutic application of biotechnology, with particular emphasis on the interplay between basic research and clinical experience. Topics to be discussed include production of hormones and other therapeutic proteins, gene therapy, oncolytic viruses, and stem cells. Reading will be from the primary literature. Prerequisite: MOL 214/215.

CBE 438 / MOL 438

Biomolecular Engineering

Professor/Instructor

A. James Link

This course will focus on the design and engineering of biomacromolecules. After a brief review of protein and nucleic acid chemistry and structure, we will delve into rational, evolutionary, and computational methods for the design of these molecules. Specific topics to be covered include aptamers, protein and RNA-based switches and sensors, unnatural amino acids and nucleotides, enzyme engineering, and the integration of these parts via synthetic biology efforts. Three lectures.

CBE 441

Chemical Reaction Engineering

Professor/Instructor

José L. Avalos

Stoichiometry and mechanisms of chemical reaction rates, both homogeneous and catalytic; adsorption, batch, continuous flow, and staged reactors; coupling between chemical reaction rates and mass, momentum, and energy transport; stability; optimization of reactor design. Application to environmental and industrial problems. Two lectures, one preceptorial. Prerequisites: CBE 246 and CBE 341.

CBE 442

Design, Synthesis, and Optimization of Chemical Processes

Professor/Instructor

Athanassios Z. Panagiotopoulos, Charles Morris Smith

Introduction to chemical process flow-sheeting; process simulation design, sizing and cost estimation of total processes; process economics; introduction to optimization, linear programming, integer programming, and nonlinear programming; heat integration methods, minimum utility cost, minimum number of units, network optimization. Three lectures, one laboratory. Prerequisites: CBE 341, CBE 346, and CBE 441.

CBE 443

Separations in Chemical and Biochemical Processes

Professor/Instructor

Robert Krafft Prud'homme

Separations of importance in biochemical and chemical processes emphasizing physical and chemical mechanisms. Topics include: membrane separations, chromatographic separations, crystallization, centrifugation, filtration, extraction, and adsorption. Three lectures.

CBE 445

Process Control

Professor/Instructor

Sankaran Sundaresan

A quantitative study of the principles of process dynamics and control. Dynamic behavior of chemical process elements; analysis and synthesis of linear feedback control systems with special emphasis on frequency response techniques and scalar systems. Two lectures. Prerequisite: MAE 305, which may be taken concurrently.

CBE 447 / GHP 457

Metabolic Engineering

Professor/Instructor

Mark Philip Brynildsen

Introduction to engineering metabolism. The objective of this course is to introduce students to current techniques and challenges within the field of metabolic engineering. Specific topics include introduction to metabolism, transcriptional regulation, signal transduction, flux balance analysis, and metabolic flux analysis. Designed for upper division students in engineering, chemistry, and molecular biology. Two lectures. Prerequisites: MOL 214 or MOL 215, or equivalent.

CBE 448 / MAT 481

Introduction to Nonlinear Dynamics

Professor/Instructor

Yannis George Kevrekidis

An introduction to the phenomenology of nonlinear dynamic behavior with emphasis on models of actual physical, chemical, and biological systems, involving an interdisciplinary approach to ideas from mathematics, computing, and modeling. The common features of the development of chaotic behavior in both mathematical models and experimental studies are stressed, as is the use of interactive graphics to explore and analyze this behavior. Two lectures. Prerequisites: knowledge of linear algebra (MAT 204) and ordinary differential equations (MAE 305).