Event details
Biosystems Design by Directed Evolution
By mimicking the Darwinian evolution in the test tube, directed evolution has become a powerful and indispensable tool for the design and engineering of biological systems including proteins, pathways, and genomes for fundamental research and biotechnological applications. In this talk, I will give a historical account of the directed evolution field and discuss the challenges and opportunities in directed evolution. I will highlight our recent work on the development and application of novel directed evolution tools for protein engineering, pathway engineering and genome engineering. Particularly, I will introduce a new directed evolution strategy that combines synthetic biology, machine learning, and laboratory automation for biosystems design.
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